Keywords Magnetically separable catalyst DETA-Fe O Knoevenagel 3 4 condensation 2,3-dihydroquinazoline-4(1H)-ones Water Environmental Introduction The easy separation and reusability of catalysts is a key factor in the selection of catalytic processes . Catalysis chemical reactions by an acid or a base immobilized on magnetic nanocatalysts (MNPs) have become a hot research topic in modern catalysis research . Among the various magnetic NPs employed as the core magnetic support, Fe O NPs have received special attention due to their 3 4 simple preparation, low toxicity, abundance and unique activities, which allow the use of mild reaction conditions in chemical transformations to achieve the corresponding ﬁnal products [3–6]. In addition, catalysis research under aqueous media is an appropriate direction for the future of organic synthesis, in particular from the point of view of green synthetic chemistry . Knoevenagel condensation of aldehydes with active methylene compounds is a well-known and extensively studied strategy for carbon–carbon bond formation in organic synthesis , because Knoevenagel products (namely the a, b -unsaturated 123 Magnetic Fe O nanoparticles supported amine… 4815 3 4 products or synthesized alkene) play a vital role in the synthesis of ﬁne chemicals , therapeutic drugs ,
Research on Chemical Intermediates – Springer Journals
Published: Mar 25, 2017
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