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Lymphocyte-to-white blood cells ratio in older patients experiencing a first acute heart failure hospitalization

Lymphocyte-to-white blood cells ratio in older patients experiencing a first acute heart failure... Purpose Low lymphocyte counts are related to poor health results in heart failure (HF) patients. We assess whether a low lymphocyte-to-white blood cells ratio (LWR) is related to 1-year mortality in older patients experiencing a first hospitaliza - tion for acute HF. Methods We evaluated 859 patients > 75 years of age admitted within a 33-month period because of a first episode of acute HF. Patients were divided into four groups according to LWR quartiles. Results Patients’ mean age was 83.5 ± 5.5 years and their median LWR was 16.7%. After 1 year of follow-up 270 patients (31.43%) died. Mean LWR values were significatively lower in the group of patients who died (15.1 vs. 17.4%; p = 0.001). Mortality rates were significantly higher in the lower LWR quartile either at 1 month, 3 months, and 1 year after the index acute HF episode. The univariate logistic regression analysis identified the LWR (either as quartiles or continuous variable) to be independently associated with higher risk of 1-year post-discharge mortality. Multivariate analysis confirmed this association (HR for LWR as a quartiles variable 1.525; 95% CI 1.161–2.003 and for LWR as a continuous variable 1.145; 95% CI 1.069–1854) besides older age, a higher comorbidity and higher admission potassium. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Geriatric Medicine Springer Journals

Lymphocyte-to-white blood cells ratio in older patients experiencing a first acute heart failure hospitalization

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Publisher
Springer Journals
Copyright
Copyright © 2018 by European Geriatric Medicine Society
Subject
Medicine & Public Health; Geriatrics/Gerontology; Internal Medicine
eISSN
1878-7657
DOI
10.1007/s41999-018-0051-5
Publisher site
See Article on Publisher Site

Abstract

Purpose Low lymphocyte counts are related to poor health results in heart failure (HF) patients. We assess whether a low lymphocyte-to-white blood cells ratio (LWR) is related to 1-year mortality in older patients experiencing a first hospitaliza - tion for acute HF. Methods We evaluated 859 patients > 75 years of age admitted within a 33-month period because of a first episode of acute HF. Patients were divided into four groups according to LWR quartiles. Results Patients’ mean age was 83.5 ± 5.5 years and their median LWR was 16.7%. After 1 year of follow-up 270 patients (31.43%) died. Mean LWR values were significatively lower in the group of patients who died (15.1 vs. 17.4%; p = 0.001). Mortality rates were significantly higher in the lower LWR quartile either at 1 month, 3 months, and 1 year after the index acute HF episode. The univariate logistic regression analysis identified the LWR (either as quartiles or continuous variable) to be independently associated with higher risk of 1-year post-discharge mortality. Multivariate analysis confirmed this association (HR for LWR as a quartiles variable 1.525; 95% CI 1.161–2.003 and for LWR as a continuous variable 1.145; 95% CI 1.069–1854) besides older age, a higher comorbidity and higher admission potassium.

Journal

European Geriatric Medicine – Springer Journals

Published: Apr 9, 2018

References

  • New onset heart failure—clinical characteristics and short-term mortality. A RICA (Spanish registry of acute heart failure) study
    Franco, J; Formiga, F; Chivite, D
  • The epidemiology of heart failure, based on data for 2.1 million inhabitants in Sweden
    Zarrinkoub, R; Wettermark, B; Wändell, P; Mejhert, M; Szulkin, R; Ljunggren, G
  • Lymphopenia as prognostic factor for mortality and hospital length of stay for elderly hospitalized patients
    Rubio-Rivas, M; Formiga, F; Grillo, S; Gili, F; Cabrera, C; Corbella, X
  • The immunological axis in heart failure: importance of the leukocyte differential
    Vaduganathan, M; Greene, SJ; Butler, J
  • Patterns of leukocyte counts on admissions for acute heart failure—presentation and outcome—results from a community based registry
    Milo-Cotter, O; Felker, GM; Uriel, N
  • Routine laboratory results and thirty day and one-year mortality risk following hospitalization with acute decompensated heart failure
    Novack, V; Pencina, M; Zahger, D
  • Low lymphocyte ratio as a novel prognostic factor in acute heart failure: results from the Pre-RELAX-AHF study
    Milo-Cotter, O; Teerlink, JR; Metra, M
  • Effectiveness of the relative lymphocyte count to predict one-year mortality in patients with acute heart failure
    Núñez, J; Núñez, E; Miñana, G
  • Utility of the neutrophil to lymphocyte ratio in predicting long-term outcomes in acute decompensated heart failure
    Uthamalingam, S; Patvardhan, EA; Subramanian, S
  • Applicability of the heart failure readmission risk score: a First European Study
    Formiga, F; Masip, J; Chivite, D; Corbella, X
  • Relative lymphocyte count: a prognostic indicator of mortality in elderly patients with congestive heart failure
    Acanfora, D; Gheorghiade, M; Trojano, L; Furgi, G; Pasini, E; Picone, C
  • The relative lymphocyte count on hospital admission is a risk factor for long-term mortality in patients with acute heart failure
    Rudiger, A; Burckhardt, OA; Harpes, P; Müller, SA; Follath, F
  • The Seattle heart failure model: prediction of survival in heart failure
    Levy, WC; Mozaffarian, D; Linker, DT
  • Chronic heart failure and inflammation: what do we really know?
    Dick, SA; Epelman, S