Ever since it was discovered that endothelial cells line lymphatic vessels, investigators have been working on unraveling the mechanisms that control the growth of this distinctive endothelium and its role in normal physiology and human disease. Recent technological advances have ushered in a new era of “omics” research on the lymphatic system. Research on the genome, transcriptome, proteome, and metabolome of lymphatics has increased our understanding of the biology of the lymphatic vasculature. Here, we introduce the context—lymphatic “systemomics,” then briefly review some of the latest advances in research on tumor-associated lymphatic vessels highlighting several “omic” studies that have shed light on mechanisms controlling the growth and function of tumor-associated lymphatic vessels. We conclude by returning, with unanswered questions, to the larger context of cancer and the lymphatic system as a vasculature, circulation, route of entry and transport, and control center of the immune network. Keywords Lymphangiogenesis · Lymphatic systemomics · Cancer · Metastasis · Tumor lymphangiogenesis Lymphatic systemomics and cancer: examine this process in relation to cancer development and lymphangiogenesis in context spread, we will return to this “systemomics” perspective to face challenges and unanswered questions that need ulti- In this focused review of lymphangiogenesis, we will first mately to be explored as identified
Clinical & Experimental Metastasis – Springer Journals
Published: May 28, 2018
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