Reactions 1680, p212 - 2 Dec 2017
Erythematous skin rash on both legs: case report
A 66-year-old woman developed erythematous skin rash on
both legs during treatment with loxoprofen [loxoprofen
sodium hydrate] and paracetamol [acetaminophen].
The woman had chronic anterior chest pain. The pain
worsened gradually. A chest radio-graph showed a small
amount of pleural effusion and proximal clavicular osteitis.
Consequently, she received treatment with paracetamol and
loxoprofen [routes and dosages not stated]. Subsequently, she
developed skin rash on both legs [time to reaction onset not
stated]. The rash was erythematous.
The woman’s therapy with loxoprofen and paracetamol was
withdrawn. The skin rash subsided gradually. The rash was
suspected to be drug induced. Drug lymphocyte stimulation
test was positive for loxoprofen and paracetamol. Later, she
was also diagnosed with synovitis-acne-pustulosis-
hyperostosis-osteitis (SAPHO) syndrome with marked sternal
osteitis and bilateral pleural effusions.
Author comment: "Her rash was erythematous and had
been suspected to be drug-induced".
Hasegawa S, et al. Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO)
syndrome with significant bilateral pleural effusions. Internal Medicine 56:
2779-2783, No. 20, 15 Oct 2017. Available from: URL: https://doi.org/10.2169/
internalmedicine.8250-16 - Japan
Reactions 2 Dec 2017 No. 16800114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved