Low-shear-modeled microgravity-grown Penicillium chrysogenum-mediated biosynthesis of silver nanoparticles with enhanced antimicrobial activity and its anticancer effect in human liver cancer and fibroblast cells

Low-shear-modeled microgravity-grown Penicillium chrysogenum-mediated biosynthesis of silver... Bioprocess Biosyst Eng (2017) 40:1529–1542 DOI 10.1007/s00449-017-1809-8 RESEARCH PAPER Low-shear-modeled microgravity-grown Penicillium chrysogenum-mediated biosynthesis of silver nanoparticles with enhanced antimicrobial activity and its anticancer effect in human liver cancer and fibroblast cells 1 1,3 2 • • • Sunirmal Sheet Yesupatham Sathishkumar Allur Subramaniyam Sivakumar 2 1 Kwan Seob Shim Yang Soo Lee Received: 5 March 2017 / Accepted: 23 June 2017 / Published online: 14 July 2017 Springer-Verlag GmbH Germany 2017 Abstract Gravitational force and shear forces induce cytotoxic studies, and anticancer activity were carried out. various changes in gene expression and metabolite pro- Antimicrobial activity was tested using antibiotic suscep- duction of microorganisms. Previous reports have shown tibility testing by Kirby–Bauer method and cytotoxicity that there are differences in the expression of different sets tests were carried out using 3T3-L1 normal fibroblasts cells of proteins and enzymes under microgravity conditions and Hep-G2 cancer cell lines. Interestingly, our results compared to normal gravity. The aim of this study is to indicated that microgravity-synthesized silver nanoparti- utilize culture filtrates of Penicillium chrysogenum grown cles possess enhanced antibacterial activity and cytotoxic under microgravity and normal conditions to synthesize effect against cancer cells compared to normal gravity- silver nanoparticles and to http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Bioprocess and Biosystems Engineering Springer Journals

Low-shear-modeled microgravity-grown Penicillium chrysogenum-mediated biosynthesis of silver nanoparticles with enhanced antimicrobial activity and its anticancer effect in human liver cancer and fibroblast cells

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Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by Springer-Verlag GmbH Germany
Subject
Chemistry; Biotechnology; Industrial and Production Engineering; Environmental Engineering/Biotechnology; Industrial Chemistry/Chemical Engineering; Food Science
ISSN
1615-7591
eISSN
1615-7605
D.O.I.
10.1007/s00449-017-1809-8
Publisher site
See Article on Publisher Site

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