Bioprocess Biosyst Eng (2017) 40:1529–1542 DOI 10.1007/s00449-017-1809-8 RESEARCH PAPER Low-shear-modeled microgravity-grown Penicillium chrysogenum-mediated biosynthesis of silver nanoparticles with enhanced antimicrobial activity and its anticancer effect in human liver cancer and ﬁbroblast cells 1 1,3 2 • • • Sunirmal Sheet Yesupatham Sathishkumar Allur Subramaniyam Sivakumar 2 1 Kwan Seob Shim Yang Soo Lee Received: 5 March 2017 / Accepted: 23 June 2017 / Published online: 14 July 2017 Springer-Verlag GmbH Germany 2017 Abstract Gravitational force and shear forces induce cytotoxic studies, and anticancer activity were carried out. various changes in gene expression and metabolite pro- Antimicrobial activity was tested using antibiotic suscep- duction of microorganisms. Previous reports have shown tibility testing by Kirby–Bauer method and cytotoxicity that there are differences in the expression of different sets tests were carried out using 3T3-L1 normal ﬁbroblasts cells of proteins and enzymes under microgravity conditions and Hep-G2 cancer cell lines. Interestingly, our results compared to normal gravity. The aim of this study is to indicated that microgravity-synthesized silver nanoparti- utilize culture ﬁltrates of Penicillium chrysogenum grown cles possess enhanced antibacterial activity and cytotoxic under microgravity and normal conditions to synthesize effect against cancer cells compared to normal gravity- silver nanoparticles and to
Bioprocess and Biosystems Engineering – Springer Journals
Published: Jul 14, 2017
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