Low Efficiency of Short-Term Tests in the Assessment of the Potential Mutagenic Hazard of Chemical Compounds to Mammals

Low Efficiency of Short-Term Tests in the Assessment of the Potential Mutagenic Hazard of... A new method of the efficiency assessment of testing mutagenicity chemical pollutants is proposed. The method is based on the selective information criterion and allows one to compare the prognostic significance of results obtained in both individual tests and test batteries. The efficiency of mutagen detection in mammals was estimated in Ames' test, the in vivo test for cytogenetic abnormalities in rodent bone-marrow cells, and the battery combining both these tests. The level of evidence for mutagenicity was determined for chemicals analyzed in these tests. Based on information obtained during the trials, a low efficiency of the analyzed tests and their battery was inferred. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Genetics Springer Journals

Low Efficiency of Short-Term Tests in the Assessment of the Potential Mutagenic Hazard of Chemical Compounds to Mammals

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Publisher
Kluwer Academic Publishers-Plenum Publishers
Copyright
Copyright © 2001 by MAIK “Nauka/Interperiodica”
Subject
Biomedicine; Human Genetics
ISSN
1022-7954
eISSN
1608-3369
D.O.I.
10.1023/A:1016711329333
Publisher site
See Article on Publisher Site

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