World J Urol (2017) 35:1255–1260 DOI 10.1007/s00345-016-1994-0 ORIGINAL ARTICLE Low amplitude rhythmic contraction frequency in human detrusor strips correlates with phasic intravesical pressure waves 1 2 3 1 Andrew F. Colhoun · John E. Speich · Lauren F. Cooley · Eugene D. Bell III · 4 1 5 1 R. Wayne Barbee · Georgi Guruli · Paul H. Ratz · Adam P. Klausner Received: 11 July 2016 / Accepted: 16 December 2016 / Published online: 26 December 2016 © Springer-Verlag Berlin Heidelberg 2016 Abstract Results Distinct LARC frequencies were identified in Purpose Low amplitude rhythmic contractions (LARC) 100% of tissue strips (n = 9) obtained with a mean fre- occur in detrusor smooth muscle and may play a role in quency of 1.97 ± 0.47 cycles/min (33 ± 8 mHz). Out of storage disorders such as overactive bladder and detrusor 100 consecutive UD studies reviewed, 35 visually dis- overactivity. The purpose of this study was to determine played phasic p waves. In 12/35 (34%), real p signals ves ves whether LARC frequencies identified in vitro from strips of were present that were independent of abdominal activity. human urinary bladder tissue correlate with in vivo LARC Average UD LARC frequency
World Journal of Urology – Springer Journals
Published: Dec 26, 2016
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