Longitudinal Effects of Syndemics on ART Non-adherence Among Sexual Minority Men

Longitudinal Effects of Syndemics on ART Non-adherence Among Sexual Minority Men This study examined longitudinally the additive effect of syndemics, or co-occurring psychosocial problems, on antiretroviral treatment (ART) non-adherence among 390 HIV-positive sexual minority men. Participants completed measures of ART adherence (reduced to a non-adherence score using exploratory factor analysis) and six syndemic conditions. We employed multilevel modeling with the number of syndemics as a longitudinal predictor of non-adherence, and logistic regression with baseline syndemics predicting follow up viral load. Number of syndemics was a significant longitudinal predictor of non-adherence, with each additional syndemic associated with a 0.13 increase in non-adherence (p = 0.004). Each additional syndemic was also associated with 1.27 greater odds of detectable viral load (p = 0.002). Among HIV-positive sexual minority men in this sample, more syndemics were associated with lower ART adherence and greater odds of detectable viral load, suggesting the need for behavioral intervention to facilitate care for this population. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AIDS and Behavior Springer Journals

Longitudinal Effects of Syndemics on ART Non-adherence Among Sexual Minority Men

11 pages
Read Article

Loading next page...
 
/lp/springer_journal/longitudinal-effects-of-syndemics-on-art-non-adherence-among-sexual-qKG8qdCls2
Publisher
Springer US
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Medicine & Public Health; Public Health; Health Psychology; Infectious Diseases
ISSN
1090-7165
eISSN
1573-3254
D.O.I.
10.1007/s10461-018-2180-8
Publisher site
See Article on Publisher Site

Abstract

This study examined longitudinally the additive effect of syndemics, or co-occurring psychosocial problems, on antiretroviral treatment (ART) non-adherence among 390 HIV-positive sexual minority men. Participants completed measures of ART adherence (reduced to a non-adherence score using exploratory factor analysis) and six syndemic conditions. We employed multilevel modeling with the number of syndemics as a longitudinal predictor of non-adherence, and logistic regression with baseline syndemics predicting follow up viral load. Number of syndemics was a significant longitudinal predictor of non-adherence, with each additional syndemic associated with a 0.13 increase in non-adherence (p = 0.004). Each additional syndemic was also associated with 1.27 greater odds of detectable viral load (p = 0.002). Among HIV-positive sexual minority men in this sample, more syndemics were associated with lower ART adherence and greater odds of detectable viral load, suggesting the need for behavioral intervention to facilitate care for this population.

Journal

AIDS and Behavior – Springer Journals

Published: Jun 2, 2018

References

  • The spectrum of engagement in HIV care and its relevance to test-and-treat strategies for prevention of HIV infection
    Gardner, EM; McLees, MP; Steiner, JF; Rio, C; Burman, WJ
  • Prevention of HIV-1 infection with early antiretroviral therapy
    Cohen, MS; Chen, YQ; McCauley, M
  • Sexual activity without condoms and risk of HIV transmission in serodifferent couples when the HIV-positive partner is using suppressive antiretroviral therapy
    Rodger, AJ; Cambiano, V; Bruun, T
  • Decreases in community viral load are accompanied by reductions in new HIV infections in San Francisco
    Das, M; Chu, PL; Santos, G-M
  • Patterns and predictors of changes in adherence to highly active antiretroviral therapy: longitudinal study of men and women
    Lazo, M; Gange, SJ; Wilson, TE
  • Prevalence of mental disorders, psychological distress, and mental health services use among lesbian, gay, and bisexual adults in the United States
    Cochran, SD; Greer, J; Mays, VM
  • Prevalence of psychiatric and substance abuse symptomatology among HIV-infected gay and bisexual men in HIV primary care
    O’Cleirigh, C; Magidson, JF; Skeer, MR; Mayer, KH; Safren, SA
  • Syndemics, sex and the city: understanding sexually transmitted diseases in social and cultural context
    Singer, MC; Erickson, PI; Badiane, L
  • Syndemics and public health: reconceptualizing disease in bio-social context
    Singer, MC; Clair, S
  • Evidence of a syndemic among young Canadian gay and bisexual men: uncovering the associations between anti-gay experiences, psychosocial issues, and HIV risk
    Ferlatte, O; Hottes, TS; Trussler, T; Marchand, R
  • High prevalence of multiple syndemic conditions associated with sexual risk behavior and HIV infection among a large sample of Spanish- and Portuguese-speaking men who have sex with men in Latin America
    Mimiaga, MJ; Biello, KB; Robertson, AM
  • Sexual compulsivity, co-occurring psychosocial health problems, and HIV risk among gay and bisexual men: further evidence of a syndemic
    Parsons, JT; Grov, C; Golub, SA
  • Association of co-occurring psychosocial health problems and increased vulnerability to HIV/AIDS among urban men who have sex with men
    Stall, R; Mills, TC; Williamson, J
  • Psychosocial health conditions and HIV prevalence and incidence in a cohort of men who have sex with men in Bangkok, Thailand: evidence of a syndemic effect
    Guadamuz, TE; McCarthy, K; Wimonsate, W
  • The effect of psychosocial syndemic production on 4-year HIV incidence and risk behavior in a large cohort of sexually active men who have sex with men
    Mimiaga, MJ; OʼCleirigh, C; Biello, KB
  • Prospective effects of a syndemic on HIV and STI incidence and risk behaviors in a cohort of young men who have sex with men
    Mustanski, B; Phillips, G; Ryan, DT; Swann, G; Kuhns, L; Garofalo, R
  • Psychosocial syndemics are additively associated with worse ART adherence in HIV-infected individuals
    Blashill, AJ; Bedoya, CA; Mayer, KH
  • An index of multiple psychosocial, syndemic conditions is associated with antiretroviral medication adherence among HIV-positive youth
    Kuhns, LM; Hotton, AL; Garofalo, R
  • Multiple syndemic psychosocial factors are associated with reduced engagement in HIV care among a multinational, online sample of HIV-infected MSM in Latin America
    Biello, KB; Oldenburg, CE; Safren, SA
  • Effects of syndemics on HIV viral load and medication adherence in the multicentre AIDS cohort study
    Friedman, MR; Stall, R; Silvestre, AJ
  • Project enhance: a randomized controlled trial of an individualized HIV prevention intervention for HIV-infected men who have sex with men conducted in a primary care setting
    Safren, SA; O’Cleirigh, CM; Skeer, M; Elsesser, SA; Mayer, KH
  • Demonstration and evaluation of a peer-delivered, individually-tailored, HIV prevention intervention for HIV-infected MSM in their primary care setting
    Safren, SA; O’Cleirigh, C; Skeer, MR
  • Developing an HIV-prevention intervention for HIV-infected men who have sex with men in HIV care: project Enhance
    Knauz, RO; Safren, SA; O’Cleirigh, C
  • Optimizing measurement of self-reported adherence with the ACTG Adherence Questionnaire: a cross-protocol analysis
    Reynolds, NR; Sun, J; Nagaraja, HN; Gifford, AL; Wu, AW; Chesney, MA
  • Psychosocial predictors of non-adherence and treatment failure in a large scale multi-national trial of antiretroviral therapy for HIV: data from the ACTG A5175/PEARLS trial
    Safren, SA; Biello, KB; Smeaton, L
  • Self-reported adherence to antiretroviral medications among participants in HIV clinical trials: the AACTG Adherence Instruments
    Chesney, MA; Ickovics, JR; Chambers, DB
  • The Juvenile Victimization Questionnaire: reliability, validity, and national norms
    Finkelhor, D; Hamby, SL; Ormrod, R; Turner, H
  • Derivation of the SPAN, a brief diagnostic screening test for post-traumatic stress disorder
    Meltzer-Brody, S; Churchill, E; Davidson, JR
  • Psychometric properties of the mini-social phobia inventory
    Seeley-Wait, E; Abbott, MJ; Rapee, RM
  • Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire
    Spitzer, RL; Kroenke, K; Williams, JB
  • Someone to count on: social support as an effect modifier of viral load suppression in a prospective cohort study
    Friedman, MR; Coulter, RWS; Silvestre, AJ; Stall, R; Teplin, L; Shoptaw, S; Surkan, PJ; Plankey, MW
  • Adherence to early antiretroviral therapy: results from HPTN 052, a phase III, multinational randomized trial of ART to prevent HIV-1 sexual transmission in serodiscordant couples
    Safren, SA; Mayer, KH; Ou, S
  • Psychometric approaches for developing commensurate measures across independent studies: traditional and new models
    Bauer, DJ; Hussong, AM
  • Reporting results of latent growth modeling and multilevel modeling analyses: some recommendations for rehabilitation psychology
    Jackson, DL
  • The influence of violations of assumptions on multilevel parameter estimates and their standard errors
    Maas, CJM; Hox, JJ
  • Persons as contexts: evaluating between-person and within-person effects in longitudinal analysis
    Hoffman, L; Stawski, RS
  • Strategies for promoting adherence to antiretroviral therapy: a review of the literature
    Simoni, JM; Amico, KR; Pearson, CR; Malow, R
  • A randomized controlled trial of cognitive behavioral therapy for adherence and depression (CBT-AD) in HIV-infected individuals
    Safren, SA; O’Cleirigh, C; Tan, JY
  • Cognitive behavioral therapy for adherence and depression (CBT-AD) in HIV-infected injection drug users: a randomized controlled trial
    Safren, SA; O’Cleirigh, CM; Bullis, JR; Otto, MW; Stein, MD; Pollack, MH
  • Cognitive behavioural therapy for adherence and depression in patients with HIV: a three-arm randomised controlled trial
    Safren, SA; Bedoya, CA; O’Cleirigh, C
  • Syndemic factors associated with HIV risk for gay and bisexual men: comparing latent class and latent factor modeling
    Starks, TJ; Millar, BM; Eggleston, JJ; Parsons, JT
  • Syndemic indicators predict poor medication adherence and increased healthcare utilization for urban HIV-positive men who have sex with men
    Pantalone, DW; Valentine, SE; Woodward, EN; O’Cleirigh, C
  • Syndemics of psychosocial problems and HIV risk: a systematic review of empirical tests of the disease interaction concept
    Tsai, AC; Burns, BFO
  • Co-occurring epidemics, syndemics, and population health
    Tsai, AC; Mendenhall, E; Trostle, JA; Kawachi, I
  • Resilience as an untapped resource in behavioral intervention design for gay men
    Herrick, AL; Lim, SH; Wei, C
  • Adversity and syndemic production among men participating in the multicenter AIDS cohort study: a life-course approach
    Herrick, AL; Lim, SH; Plankey, MW; Chmiel, JS; Guadamuz, TT; Kao, U; Shoptaw, S; Carrico, A; Ostrow, D; Stall, R
  • The association of individual and systemic barriers to optimal medical care in people living with HIV/AIDS (PLWHA) in Miami-Dade County
    Wawrzyniak, AJ; Rodríguez, AE; Falcon, AE

You’re reading a free preview. Subscribe to read the entire article.

Try 2 weeks free now

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

or browse the journals available

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off

Sign up
for free
Start 14 day
Free Trial