Eur J Clin Pharmacol (2017) 73:1149–1158 DOI 10.1007/s00228-017-2273-8 PHARMACOEPIDEMIOLOGY AND PRESCRIPTION Long-term use of proton pump inhibitors among community-dwelling persons with and without Alzheimer’s disease 1,2 1,2,3 3,4 1,2 Heidi Juntunen & Heidi Taipale & Antti Tanskanen & Anna-Maija Tolppanen & 3,4 1,2 1,2 Jari Tiihonen & Sirpa Hartikainen & Miia Tiihonen Received: 6 April 2017 /Accepted: 24 May 2017 /Published online: 2 June 2017 Springer-Verlag Berlin Heidelberg 2017 Abstract among persons with than without AD (20.3 and 17.9%, re- Purpose The aim of this study is to determine the prevalence spectively, p < 0.001). Factors related to long-term use of PPIs of use and long-term use (≥180 days) of proton pump inhib- were female sex, history of gastrointestinal bleedings, AD, itors (PPIs) and associated factors among community- rheumatoid arthritis, cardiovascular disease, asthma/COPD dwellers with and without Alzheimer’s disease (AD). and use of bisphosphonates, SSRIs and antithrombotic agents. Methods MEDALZ cohort encompassed all persons who re- Median follow-up time was 2.6 years among persons with AD ceived a verified diagnosis of AD in Finland during the years and 3.5 years among persons without AD. Median duration of 2005–2011 and their age-, sex-, and region of residence- the first long-term
European Journal of Clinical Pharmacology – Springer Journals
Published: Jun 2, 2017
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