Background Tumor recurrence during the ﬁrst year after oncological esophagectomy has been reported in up to 17–66% of patients. However, little is known as to the risk factors potentially associated with this adverse outcome. The aim of this retrospective observational study was to identify clinically relevant parameters associated with early recurrence. Methods All patients with squamous cell cancer or adenocarcinoma of the esophagus or gastroesophageal junction, operated with curative intent in our center from 2000 to 2014, were screened for this study. Univariate analysis was conducted to identify variables potentially associated with early recurrence, and clinically relevant parameters with P \ 0.1 were included in multiple logistic regression. Survival analyses were conducted with the Kaplan–Meier method. Signiﬁcance threshold was set at P \ 0.05. Results Among the 164 included patients, 46 (28%) presented early recurrence. Eight patients (17.4%) had locoregional and 38 patients (82.6%) metastatic recurrence. Advanced T and N stages, lymph node capsular effraction, a high positive-to-resected lymph node ratio, positive resection margins, poor response to neoadjuvant treatment, preoperative active smoking, malnutrition and dysphagia were associated with early recurrence on a univariate level. In multivariable analysis, preoperative smoking (OR 2.76, 95% CI 1.28–6.17), pT stage (OR 1.72, 95%
World Journal of Surgery – Springer Journals
Published: Dec 28, 2017
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