Mammalian Genome 8, 45--46 (1997). e//o///e 9 Springer-Verlag New York Inc. 1997 Localization of Zap70, the gene for a T cell-specific protein tyrosine kinase, to mouse and rat chromosomes by fluorescence in situ hybridization and molecular genetic linkage analyses T. Saito, 1 Y. Matsuda, 1 H. Ito, 1 N. Fusaki, z T. Hori, 1 T. Yamamoto 2 1Division of Genetics, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263, Japan 2Department of Oncology, Institute of Medical Science, Tokyo University, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108, Japan Received: 1 September 1995 / Accepted: 23 August 1996 Zap70, the gene for a non-SRC type protein tyrosine kinase that ease (Arpaia et al. 1994; Chan et al. 1994; Elder et al. 1994). These has recently been demonstrated to play an essential role in T cell studies indicated that absence of the ZAP70 protein results in an development and function, was mapped to mouse Chromosome inability to mediate the signals of T cell receptor and produces a (Chr) 1B and rat Chr 9q22.1 by direct R-banding fluorescence in distinctive form of human severe combined immunodeficiency. situ hybridization (FISH). The gene was localized also by genetic Although detailed basic biochemical studies on the mechanism
Mammalian Genome – Springer Journals
Published: Mar 23, 2009
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