Mammalian Genome 9, 910–912 (1998). Incorporating Mouse Genome © Springer-Verlag New York Inc. 1998 Localization of tub and uncoupling proteins (Ucp) 2 and 3 to a region of rat Chromosome 1 linked to glucose intolerance and adiposity in the Goto-Kakizaki (GK) Type 2 diabetic rat Pamela J. Kaisaki, Peng Y. Woon, Robert H. Wallis, Anthony P. Monaco, Mark Lathrop, Dominique Gauguier The Wellcome Trust Centre for Human Genetics, Headington, Oxford OX3 7BN, UK Received: 30 April 1998 / Accepted: 10 July 1998 Uncoupling proteins (UCP) 2 and UCP3 are closely related to the 1997). In addition, a rat PAC library was screened by PCR of PAC mitochondrial membrane protein UCP1, which can dissociate res- DNA superpools, followed by colony hybridization (Woon et al. piration from ATP synthesis, resulting in the generation of heat 1998; http://bacpac.med.buffalo.edu). One phage clone for tub (Fleury et al. 1997; Boss et al. 1997; Vidal-Puig et al. 1997). (rTub1) and three PAC clones containing both Ucp2 and Ucp3 Because this property may allow for disposal of excess energy, (PACs 80A20, 126H1, and 189A21) were isolated. The insert size uncoupling proteins are regarded as potential candidate genes for of rTub1 is approximately 5 kb, and the
Mammalian Genome – Springer Journals
Published: Nov 1, 1998
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