Mammalian Genome 8,586-588 (1997). 9 Springer-Verlag New York Inc. 1997 Localization of the rat genes encoding glucagon, glucagon receptor, and insulin receptor, candidates for diabetes mellitus susceptibility loci Claude Szpirer, 1 Josiane Szpirer, 1 Pascole Vanvooren, 1 Mich~le Rivi~re, 1 Barbara Maget, 2 Michal Svoboda, 2 Masahide Shiozawa, 3'4 Jason S. Simon, 3 Howard J. Jacob, 3'4, George Koike 3'4 ~D6partement de Biologic Mol6culaire, Universit6 Libre de Bruxelles, Rue des Chevaux, 67, B-1640 Rhode-St-Gen~se, Belgium aLaboratoire de Chimie Biologique, Facult6 de M6decine, Universit6 Libre de Bruxelles, B-1070 Bruxelles, Belgium 3Cardiovascular Research Center, Massachusetts General Hospital-East, 149 13 th Street, 4 t~ Floor, Charlestown, Massachusetts 02129, USA 4Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226-0509, USA Received: 28 December 1996 / Accepted: 17 March 1997 The rat is one of the best-characterized animal models for studying We screened a rat genomic library (Stratagene Cloning Systems, genetic susceptibility to both insulin-dependent diabetes mellitus La Jolla, Calif.; independent plaques: 2.0 x 106), prepared by (IDDM) and non-insulin-dependent diabetes mellitus (NIDDM). partial Sau3AI digests of genomic DNA isolated from Fischer Several loci implicated in these genetic disorders have been ge- male rat liver and cloned into the
Mammalian Genome – Springer Journals
Published: Apr 1, 2009
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