Localization of the rat genes encoding glucagon, glucagon receptor, and insulin receptor, candidates for diabetes mellitus susceptibility loci

Localization of the rat genes encoding glucagon, glucagon receptor, and insulin receptor,... Mammalian Genome 8,586-588 (1997). 9 Springer-Verlag New York Inc. 1997 Localization of the rat genes encoding glucagon, glucagon receptor, and insulin receptor, candidates for diabetes mellitus susceptibility loci Claude Szpirer, 1 Josiane Szpirer, 1 Pascole Vanvooren, 1 Mich~le Rivi~re, 1 Barbara Maget, 2 Michal Svoboda, 2 Masahide Shiozawa, 3'4 Jason S. Simon, 3 Howard J. Jacob, 3'4, George Koike 3'4 ~D6partement de Biologic Mol6culaire, Universit6 Libre de Bruxelles, Rue des Chevaux, 67, B-1640 Rhode-St-Gen~se, Belgium aLaboratoire de Chimie Biologique, Facult6 de M6decine, Universit6 Libre de Bruxelles, B-1070 Bruxelles, Belgium 3Cardiovascular Research Center, Massachusetts General Hospital-East, 149 13 th Street, 4 t~ Floor, Charlestown, Massachusetts 02129, USA 4Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226-0509, USA Received: 28 December 1996 / Accepted: 17 March 1997 The rat is one of the best-characterized animal models for studying We screened a rat genomic library (Stratagene Cloning Systems, genetic susceptibility to both insulin-dependent diabetes mellitus La Jolla, Calif.; independent plaques: 2.0 x 106), prepared by (IDDM) and non-insulin-dependent diabetes mellitus (NIDDM). partial Sau3AI digests of genomic DNA isolated from Fischer Several loci implicated in these genetic disorders have been ge- male rat liver and cloned into the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Mammalian Genome Springer Journals

Localization of the rat genes encoding glucagon, glucagon receptor, and insulin receptor, candidates for diabetes mellitus susceptibility loci

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Publisher
Springer-Verlag
Copyright
Copyright © 1997 by Springer-Verlag
Subject
Life Sciences; Cell Biology; Anatomy; Zoology
ISSN
0938-8990
eISSN
1432-1777
D.O.I.
10.1007/s003359900510
Publisher site
See Article on Publisher Site

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