Mammalian Genome 9, 593–594 (1998). Incorporating Mouse Genome © Springer-Verlag New York Inc. 1998 Localization of the genes encoding the type I diabetes autoantigens, protein-tyrosine phosphatases IA2 and IAR 1 1 2 2 1 2 Grant Morahan, Dexing Huang, Wei-Ping Yu, Lin Cui, Henry DeAizpurua, Catherine J. Pallen The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria, 3050, Australia Institute of Molecular and Cell Biology, National University of Singapore, 17 Kent Ridge Crescent, Singapore 119076, Republic of Singapore Received: 27 October 1997 / Accepted: 21 February 1998 Type I diabetes, or insulin-dependent diabetes mellitus (IDDM), is an autoimmune disease, involving destruction of insulin-producing pancreatic islet b cells; it is a complex genetic disease, in which both HLA and non-HLA genes contribute to susceptibility (see review by Bach 1994). A number of non-HLA genes have been mapped, although their gene products have not yet been identified. Several autoantigens have been defined by sera from IDDM sub- jects. These autoantigens include two protein tyrosine phosphata- ses (PTPs): the transmembrane molecules IA-2 (also termed ICA 512) and IAR (also termed phogrin; Rabin et al. 1994; Lan et al. 1994; Cui et al. 1996; Kawasaki et al. 1996).
Mammalian Genome – Springer Journals
Published: Jul 1, 1998
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