Mammalian Genome 8, 56-59 (1997). e llOme @ Springer.Verlag New York Inc. 1997 Localization of the cell death genes CPP32 and Mch-2 to human Chromosome 4q J. Nasir, 1 J.L Theilmann, l V. Chopra, 1 A.M. Jones, 2 D. Walker, 2 D.M. Rasper, a J.P. Vaillancourt, 3 J.E. Hewitt, 2 D.W. Nicholson, 3 M.R. Hayden l 1Department of Medical Genetics and Centre for Molecular Medicine & Therapeutics (CMMT), University of British Columbia, Vancouver, British Columbia, V6T 1Z4, Canada 2School of Biological Sciences, The University of Manchester, England, UK 3Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Montreal, Canada Received: 29 April 1996 / Accepted: 13 August 1996 Positive hybridization signals were observed only in three YACs Programmed cell death, manifested as apoptosis, is a deliberate and systematic means of cell suicide characterized by several dis- (Fig. 2). These YACs (23BA6, 16GH9 and 35EB2) map to the tinct biochemical and morphological changes including cell proximal end of the contig (Fig. 3). CPP32 therefore maps between shrinkage, membrane blebbing, and chromatin condensation the blood factor loci KLK3/FXI and D4S254 and is contained (Wyllie et al. 1980). While this mechanism for self-destruction can within the same 240-kb YAC
Mammalian Genome – Springer Journals
Published: Mar 23, 2009
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