Liver Injury from Herbs and “Dietary Supplements”: Highlights of a Literature Review from 2015 to 2017

Liver Injury from Herbs and “Dietary Supplements”: Highlights of a Literature Review from... Purpose of the Review To present highlights of recent liver injury from herbs and “dietary supplements,” based on a literature review from 2015 to 2017. Recent findings Challenging are quality issues of herb and dietary supplements (HDS) products, influenced by the circadian clock system in plants that controls many important metabolic pathways including photosynthesis and molecular processes of gene expression. Important also is plant stress, caused by pathogen attacks, heavy UV radiation, draft, soil contamination by salts or heavy metals, involving oxidative stress through generation of free radicals including reactive oxygen species (ROS), dam- aging the plant’s integrity. Finally, expectations are high if physicians publish case reports of HDS liver injury using the Roussel Uclaf Causality Assessment Method (RUCAM), but intentional overscoring of causality gradings must be resisted. In critical situations, reevaluation of original case data was a good approach clarifying divergencies. Summary Plant stress impairs the quality of herbs, requiring better understanding of plant physiology, and clinical liver injury cases need better causality assessment using RUCAM. . . . . Keywords Herb-induced liver injury Herbal and dietary supplement liver injury Herbal product quality Causality assessment . . . RUCAM Roussel Uclaf Causality Assessment Method Plant physiology plant chronobiology http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Pharmacology Reports Springer Journals

Liver Injury from Herbs and “Dietary Supplements”: Highlights of a Literature Review from 2015 to 2017

Loading next page...
 
/lp/springer_journal/liver-injury-from-herbs-and-dietary-supplements-highlights-of-a-nKXyP9aiuy
Publisher
Springer International Publishing
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Biomedicine; Pharmacology/Toxicology; Biomedicine, general; Cancer Research; Molecular Medicine
eISSN
2198-641X
D.O.I.
10.1007/s40495-018-0124-7
Publisher site
See Article on Publisher Site

Abstract

Purpose of the Review To present highlights of recent liver injury from herbs and “dietary supplements,” based on a literature review from 2015 to 2017. Recent findings Challenging are quality issues of herb and dietary supplements (HDS) products, influenced by the circadian clock system in plants that controls many important metabolic pathways including photosynthesis and molecular processes of gene expression. Important also is plant stress, caused by pathogen attacks, heavy UV radiation, draft, soil contamination by salts or heavy metals, involving oxidative stress through generation of free radicals including reactive oxygen species (ROS), dam- aging the plant’s integrity. Finally, expectations are high if physicians publish case reports of HDS liver injury using the Roussel Uclaf Causality Assessment Method (RUCAM), but intentional overscoring of causality gradings must be resisted. In critical situations, reevaluation of original case data was a good approach clarifying divergencies. Summary Plant stress impairs the quality of herbs, requiring better understanding of plant physiology, and clinical liver injury cases need better causality assessment using RUCAM. . . . . Keywords Herb-induced liver injury Herbal and dietary supplement liver injury Herbal product quality Causality assessment . . . RUCAM Roussel Uclaf Causality Assessment Method Plant physiology plant chronobiology

Journal

Current Pharmacology ReportsSpringer Journals

Published: Feb 14, 2018

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches

$49/month

Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.

$588

$360/year

billed annually
Start Free Trial

14-day Free Trial