Liver fibrosis: stretched exponential model outperforms mono-exponential and bi-exponential models of diffusion-weighted MRI

Liver fibrosis: stretched exponential model outperforms mono-exponential and bi-exponential... Objectives To compare the ability of diffusion-weighted imaging (DWI) parameters acquired from three different models for the diagnosis of hepatic fibrosis (HF). Methods Ninety-five patients underwent DWI using nine b values at 3 T magnetic resonance. The hepatic apparent diffusion coefficient (ADC) from a mono-exponential model, the true diffusion coefficient (D ), pseudo-diffusion coefficient (D ) and t p perfusion fraction (f) from a biexponential model, and the distributed diffusion coefficient (DDC) and intravoxel heterogeneity index (α) from a stretched exponential model were compared with the pathological HF stage. For the stretched exponential # # model, parameters were also obtained using a dataset of six b values (DDC , α ). The diagnostic performances of the parameters for HF staging were evaluated with Obuchowski measures and receiver operating characteristics (ROC) analysis. The measure- ment variability of DWI parameters was evaluated using the coefficient of variation (CoV). Results Diagnostic accuracy for HF staging was highest for DDC (Obuchowski measures, 0.770 ± 0.03), and it was significantly higher than that of ADC (0.597 ± 0.05, p <0.001), D (0.575 ± 0.05, p <0.001) and f (0.669 ± 0.04, p = 0.035). The parameters from stretched exponential DWI and D showed higher http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Radiology Springer Journals

Liver fibrosis: stretched exponential model outperforms mono-exponential and bi-exponential models of diffusion-weighted MRI

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Publisher
Springer Journals
Copyright
Copyright © 2018 by European Society of Radiology
Subject
Medicine & Public Health; Imaging / Radiology; Diagnostic Radiology; Interventional Radiology; Neuroradiology; Ultrasound; Internal Medicine
ISSN
0938-7994
eISSN
1432-1084
D.O.I.
10.1007/s00330-017-5292-z
Publisher site
See Article on Publisher Site

Abstract

Objectives To compare the ability of diffusion-weighted imaging (DWI) parameters acquired from three different models for the diagnosis of hepatic fibrosis (HF). Methods Ninety-five patients underwent DWI using nine b values at 3 T magnetic resonance. The hepatic apparent diffusion coefficient (ADC) from a mono-exponential model, the true diffusion coefficient (D ), pseudo-diffusion coefficient (D ) and t p perfusion fraction (f) from a biexponential model, and the distributed diffusion coefficient (DDC) and intravoxel heterogeneity index (α) from a stretched exponential model were compared with the pathological HF stage. For the stretched exponential # # model, parameters were also obtained using a dataset of six b values (DDC , α ). The diagnostic performances of the parameters for HF staging were evaluated with Obuchowski measures and receiver operating characteristics (ROC) analysis. The measure- ment variability of DWI parameters was evaluated using the coefficient of variation (CoV). Results Diagnostic accuracy for HF staging was highest for DDC (Obuchowski measures, 0.770 ± 0.03), and it was significantly higher than that of ADC (0.597 ± 0.05, p <0.001), D (0.575 ± 0.05, p <0.001) and f (0.669 ± 0.04, p = 0.035). The parameters from stretched exponential DWI and D showed higher

Journal

European RadiologySpringer Journals

Published: Feb 5, 2018

References

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