Lithium overdose

Lithium overdose Reactions 1680, p208 - 2 Dec 2017 O S Lithium toxicity and arrhythmic complications following suicide attempt: case report A man in his 60s [age not clearly stated] developed lithium toxicity, prolonged QTc interval and right bundle-branch block following lithium [lithium carbonate] overdose in a suicide attempt. The man was hospitalised for significant lithium overdose. He had a history of recurrent depressive disorder. Prior to admission, he was taking lithium 800mg once a night along with other treatment medications. He had recently been diagnosed with a rare skin carcinoma (on his legs). He underwent radical surgery for the skin carcinoma. He reported this surgery to be distressing. A year before admission, he became socially isolated following a relationship breakdown. He self-administered 50x400mg lithium along with a pint of beer with an intention of suicide. Twelve hours later, he experienced diarrhoea, dizziness, abdominal pain and profuse vomiting. He reported this overdose to the admitting staff and paramedics. He was dehydrated at the time of admission. Past pointing and cerebellar ataxia were noted on neurological examination. Creatinine level increased from 75 µmol/L to 108 µmol/L and bicarbonate level was at 28.1 mmol/L. The serum lithium level (after 12 hours of overdose) was 4.7 mEq/L (normal therapeutic range 0.4-1.0 mEq/L). ECG revealed a prolonged QTc of 490ms and right bundle-branch block. The man was started on haemofiltration and received 3 cycles of therapy. His all psychotropic medications were withheld. Following third haemofiltration, the serum lithium level reduced to 0.88 mEq/L. Six days after the overdose, when the man’s serum lithium level reached 0.67 mEq/L, treatment with lithium was started again. Twenty four hours after starting lithium, he presented with dysarthria, bilateral tremor and dystonia. At this point of time, his serum levels were within normal therapeutic range. He was transferred to a psychiatric hospital. He again showed signs of catatonic stupor. Therefore, he was detained and electroconvulsive therapy was administered. Author comment: "Here we describe a case of severe lithium overdose." "Lithium neurotoxicity is a potential complication of lithium therapy, most typically in patients on chronic lithium who experience an acute overdose". De Cates AN, et al. Lithium overdose and delayed severe neurotoxicity: Timing for renal replacement therapy and restarting of lithium. BMJ Case Reports 2017: 222453, 25 Oct 2017. Available from: URL: bcr-2017-222453 - United Kingdom 803284571 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 Reactions Weekly Springer Journals

Lithium overdose

Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Springer International Publishing
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
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