Lithium/moxifloxacin interaction

Lithium/moxifloxacin interaction Reactions 1680, p209 - 2 Dec 2017 Lithium thoxicity: case report A 74-year-old woman developed lithium toxicity following concomitant administration of lithium and moxifloxacin. The woman, who had a history of the bipolar affective disorder, was started on lithium 600 mg/day (300mg in the morning and 300mg at night) [route not stated], along with haloperidol and risperidone, in 2010. Her lithium concentration ranged from 0.60 0.80 mmol/L. She presented to the emergency department with myoclonic jerks of the upper extremities, slurred speech, exhaustion and severe tremor in both hands, on 15 January 2016. Of note, her symptoms began a day after she started taking moxifloxacin 400 mg/day for bronchitis [route not stated]. Subsequent physical examination and other laboratory tests in the emergency department were unremarkable. Her lithium level was noted at 1.7 mEq/L. Her electrocardiography and cranial magnetic resonance imaging were normal. Hypoxia, hypoglycaemia, hypothermia or hyperthermia, electrolyte disorders, central nervous system infection, head trauma, intracranial bleeding and neuroleptic malignant syndrome were ruled out. Thereafter, she was diagnosed with the mild- moderate toxicity of lithium. Lithium and moxifloxacin were discontinued and fluid resuscitation with saline solution was employed. The lithium level was measured at 0.9 mEq/L, after 12 hours, and tremors and myoclonic jerks subsided. In the following week, the remaining symptoms resolved. Author comment: "Result of the Naranjo Adverse Drug Reaction Probability Scale in this case, indicated a ’probable’ (score, 6) interaction between lithium and moxifloxacin." "[S]he was diagnosed with mild-moderate toxicity of lithium." Kayipmaz S, et al. Lithium intoxication: A possible interaction with moxifloxacin. Clinical Psychopharmacology and Neuroscience 15: 407-409, No. 4, 2017. Available from: URL: - Turkey 803284887 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 Reactions Weekly Springer Journals

Lithium/moxifloxacin interaction

Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
1 page

Loading next page...
1 Page
Springer International Publishing
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
Publisher site
See Article on Publisher Site


You’re reading a free preview. Subscribe to read the entire article.

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches


Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.



billed annually
Start Free Trial

14-day Free Trial