Reactions 1704, p230 - 2 Jun 2018 Angioedema: case report A 69-year-old woman developed angioedema following treatment with lisinopril [route, dosage, indication and duration of treatment to reaction onset not stated]. The woman, who had a significant medical history of chronic obstructive pulmonary disease, hypertension and tobacco use, presented to the emergency department (ED) for swollen tongue, lips and change of voice. She had experienced vomiting and diarrhoea after dinner the previous night. Three months previously, she had developed a similar episode, which was treated with diphenhydramine [Benadryl]. She was receiving treatment with lisinopril, aspirin, amlodipine and atorvastatin. At the ED, the woman was treated with diphenhydramine, famotidine and unspecified corticosteroids. A fiberoptic laryngoscopy revealed swollen base of the tongue and arytenoid process. Therefore, she was intubated for airway protection and received fresh frozen plasma for persistent swelling. On day 3, her condition improved, and she extubated. The episode of angioedema was considered secondary to lisinopril. She was then discharged with aspirin and amlodipine. Upon follow-up, she was asymptomatic. Author comment: "By exclusion, this episode of angioedema was attributed to lisinopril." "Angioedema is a rare but life-threatening side effect of angiotensin-converting enzyme inhibitor (ACEI)." Ahmed SU, et al. Angioedema, an uncommon side effect of Angiotensin- converting enzyme Inhibitor use. Journal of the American Geriatrics Society 66 (Suppl. 2): S188, Apr 2018. Available from: URL: https://doi.org/10.1111/ jgs.15376 [abstract] - USA 803323446 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704
Reactions Weekly – Springer Journals
Published: Jun 2, 2018
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