Lisdexamfetamine Reactions 1680, p205 - 2 Dec 2017 Exacerbation of haematophobia and syncope: case report A 19-year-old woman developed exacerbation of haematophobia and syncope during treatment with lisdexamfetamine [route, times to reactions onsets and outcomes not stated]. The woman had attention deficit hyperactivity disorder including depression and obsessions, and a life-long haematophobia. She used to feel presyncopal with blood draws. Various examinations were performed. Base on the finding of these examinations, she was started on lisdexamfetamine 20 mg/day. A notable improvement was seen in the symptoms of attention deficit hyperactivity disorder along with resolution of her depression, anxiety and obsessions. However, a significant exacerbation of her haematophobia was noted concurrently. This exacerbation manifested as an elevated emotional and physiological response. Syncope was seen on phlebotomy with recurrent haematophobia-induced syncope, for which she required a visit to the emergency department. Author comment: "Lisdexamfetamine, a prodrug of dextroamphetamine, used in the treatment of attention deficit hyperactivity disorder and binge eating disorder, has been described to exacerbate a plethora of psychiatric disorders." However, this patient’s hematophobia and associated syncope were exacerbated, the mechanism by which is unclear." Chand MR, et al. Lisdexamfetamine augmentation of hematophobia. CNS Spectrums 22: 83 abstr. 137, No. 1, Feb 2017. Available from: URL: http:// [abstract] - USA 803284955 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 Reactions Weekly Springer Journals


Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Springer International Publishing
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
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