Liquid crystal biosensor for detecting ischemia modified albumin

Liquid crystal biosensor for detecting ischemia modified albumin Ischemia modified albumin detection has great significance in early diagnosis and treatment of myocardial ischemia. In this study, anti-IMA was immobilized on the surface of a glass slide using self-assembled DMOAP and PEI, the binding of antibody and antigen lead to topology-geomorphologic changes on the slide surface, which induced 5CB molecules orientation transformation and modulated light transmittance. Results showed that we can detect concentrations as low as 50 μg/mL IMA. Moreover, this method can be realized with label-free, easy operation without dependence on equipment, and can be observed by the naked eye. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Liquid crystal biosensor for detecting ischemia modified albumin

Loading next page...
 
/lp/springer_journal/liquid-crystal-biosensor-for-detecting-ischemia-modified-albumin-KkMiGeKFzA
Publisher
Springer Netherlands
Copyright
Copyright © 2016 by The Author(s)
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-016-2626-4
Publisher site
See Article on Publisher Site

Abstract

Ischemia modified albumin detection has great significance in early diagnosis and treatment of myocardial ischemia. In this study, anti-IMA was immobilized on the surface of a glass slide using self-assembled DMOAP and PEI, the binding of antibody and antigen lead to topology-geomorphologic changes on the slide surface, which induced 5CB molecules orientation transformation and modulated light transmittance. Results showed that we can detect concentrations as low as 50 μg/mL IMA. Moreover, this method can be realized with label-free, easy operation without dependence on equipment, and can be observed by the naked eye.

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Jul 25, 2016

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve Freelancer

DeepDyve Pro

Price
FREE
$49/month

$360/year
Save searches from
Google Scholar,
PubMed
Create lists to
organize your research
Export lists, citations
Read DeepDyve articles
Abstract access only
Unlimited access to over
18 million full-text articles
Print
20 pages/month
PDF Discount
20% off