J. Membrane Biol. 191, 87–97 (2003) DOI: 10.1007/s00232-002-1046-0 Topical Review P.-A. Monnard Department of Molecular Biology, Massachusetts General Hospital, Wellman 9, 50 Blossom St., Boston, MA 02114, USA Received: 5 April 2002/Revised: 14 August 2002 Introduction enzyme. Microsize vesicle-based bioreactors could be developed that combine both the properties of bio- The ﬁrst enzyme-containing lipid vesicles were de- logical and nanotechnological systems. Such systems veloped soon after the pioneering work of Bangham would represent a kind of artiﬁcial minimal cell et al. (1964, 1965) that outlined the physical proper- (Pohorille & Deamer, 2002), and could be engineered ties of these lipid structures in an aqueous medium. for a speciﬁc task related to therapeutic and diag- Such systems have been envisioned as drug-delivery nostic applications. Unlike genetically modiﬁed cells vehicles for gene therapy or enzyme-replacement that require stringent conditions to survive and can therapy and as bioreactors, which could ultimately be damaged during genetic manipulations, these li- serve as microcompartments for in vitro selection of, posome-based bioreactors would only be composed e.g., catalytic RNA (ribozymes), or as blueprints for of the desired genetic material or/and metabolic ac- an artiﬁcial minimal cell. tivity, thereby overcoming safety and ethical issues Amphiphile vesicles with
The Journal of Membrane Biology – Springer Journals
Published: Jan 1, 2003
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera