Mammalian Genome 8, 938-940 (1997). ellOllle 9 Spfinger-Verlag New York Inc. 1997 Linkage mapping of wool keratin and keratin-associated protein genes in sheep Robert J. McLaren, a Geraldine R. Rogers, 2 Kizanne P. Davies, 3 Jill F. Maddox, 3 Grant W. Montgomery 1 1AgResearch Molecular Biology Unit, Department of Biochemistry and Centre for Gene Research, University of Otago, P.O. Box 56, Dunedin, New Zealand 2Wool Research Organisation of New Zealand, Private Bag 4749, Christchurch, New Zealand 3Centre for Animal Biotechnology, University of Melbourne, Parkville, Australia Received: 5 March 1997 / Accepted: 8 August 1997 The keratins and keratin-associated proteins (KAPs) are a large 1993). However, Fietz and associates (1990) reported a Tricho- heterogeneous group of proteins that make up about 90% of the hyalin eDNA clone lacking three complete and one partial repeat wool fiber. Heteropolymers of the type I and type II keratins unit within this region compared with the genomic clone, and the (encoded by the KRTI.n and KRT2.n gene families respectively) 650-bp PCR amplimer obtained is consistent with the sequence of form the microfibrils of the wool fiber (Powell and Rogers 1994). this eDNA. These microfibrils are embedded in a matrix of KAPs. The KAPs The
Mammalian Genome – Springer Journals
Published: Mar 21, 2009
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