Linkage disequilibrium mapping reveals suppressed recombination at the Os locus

Linkage disequilibrium mapping reveals suppressed recombination at the Os locus Mammalian Genome 9, 681–682 (1998). Incorporating Mouse Genome © Springer-Verlag New York Inc. 1998 Linkage disequilibrium mapping reveals suppressed recombination at the Os locus 1, 2 1 1, 1,3 2 O. Lenz, * U. Teichmann, A. Langers, L.J. Striker, * G.E. Striker, W.J. Pavan Renal Cell Biology Section, Metabolic Diseases Branch, National Institutes for Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA Laboratories for Genetic Disease Research, Building 49, National Human Genome Research Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, USA IVAX Research Institute, Miami, Florida 33137, USA Received: 27 January 1998 / Accepted: 10 April 1998 The Oligosyndactylism(Os) mutation was induced in 1952 by Given that Os is a radiation-induced mutation, it is possible W. Russell at the Oak Ridge Laboratories by irradiation of a that one or more inversions, insertions or deletions could be pre- (101xC3H)F male mouse. An offspring derived from matings sent that disrupt one or more genes, resulting in the mitotic arrest with this male exhibited oligosyndactylism on all feet (Gruneberg and or limb phenotypes. This event could also explain the sup- 1956). In addition to abnormalities in limb formation, Os/+ ani- pressed recombination along Mammalian Genome Springer Journals

Linkage disequilibrium mapping reveals suppressed recombination at the Os locus

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Copyright © 1998 by Springer-Verlag New York Inc.
Life Sciences; Cell Biology; Animal Genetics and Genomics; Human Genetics
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