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Linezolid

Linezolid Reactions 1704, p228 - 2 Jun 2018 Various toxicities: case report A 52-year-old woman developed linezolid induced mitochondrial toxicity manifesting as abdominal pain, altered mental status, asthenia, hypotension, tachycardia, acute pancreatitis, hypoglycaemia and lactic acidosis during treatment with linezolid [route and dosage not stated]. The woman, who had recurrent diverticulitis complicated by abscess formation and multiple perforations along with multiple IR drainages, exploratory laparotomy, and s/p ileostomy with small bowel resection was discharged on linezolid and ertapenem. However, on 56 day of linezolid therapy, she developed asthenia, altered mental status and acute on chronic abdominal pain. She was hypoglycaemic, hypotensive and tachycardic. Initially, septic shock due to intra-abdominal abscess was assumed and she was hospitalised. Considering the radiographic evidence of peri- pancreatic fat stranding, she was treated for acute pancreatitis. She received fluids, piperacillin/tazobactam, vancomycin along with norepinephrine bitartrate, and was urgently dialysed. Clinical investigations revealed marked and persistent lactic acidosis. Considering the other investigations, infectious etiology was ruled out. A diagnosis of linezolid induced mitochondrial toxicity was made. The woman’s antibiotics were discontinued. Subsequently, her laboratory parameters normalised.She was then transferred back for further rehabilitation. Author comment: "Here we present a case of linezolid toxicity in a patient http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Linezolid

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018
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Linezolid

Abstract

Reactions 1704, p228 - 2 Jun 2018 Various toxicities: case report A 52-year-old woman developed linezolid induced mitochondrial toxicity manifesting as abdominal pain, altered mental status, asthenia, hypotension, tachycardia, acute pancreatitis, hypoglycaemia and lactic acidosis during treatment with linezolid [route and dosage not stated]. The woman, who had recurrent diverticulitis complicated by abscess formation and multiple perforations along with multiple IR drainages, exploratory...
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References (1)

Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
DOI
10.1007/s40278-018-46871-1
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p228 - 2 Jun 2018 Various toxicities: case report A 52-year-old woman developed linezolid induced mitochondrial toxicity manifesting as abdominal pain, altered mental status, asthenia, hypotension, tachycardia, acute pancreatitis, hypoglycaemia and lactic acidosis during treatment with linezolid [route and dosage not stated]. The woman, who had recurrent diverticulitis complicated by abscess formation and multiple perforations along with multiple IR drainages, exploratory laparotomy, and s/p ileostomy with small bowel resection was discharged on linezolid and ertapenem. However, on 56 day of linezolid therapy, she developed asthenia, altered mental status and acute on chronic abdominal pain. She was hypoglycaemic, hypotensive and tachycardic. Initially, septic shock due to intra-abdominal abscess was assumed and she was hospitalised. Considering the radiographic evidence of peri- pancreatic fat stranding, she was treated for acute pancreatitis. She received fluids, piperacillin/tazobactam, vancomycin along with norepinephrine bitartrate, and was urgently dialysed. Clinical investigations revealed marked and persistent lactic acidosis. Considering the other investigations, infectious etiology was ruled out. A diagnosis of linezolid induced mitochondrial toxicity was made. The woman’s antibiotics were discontinued. Subsequently, her laboratory parameters normalised.She was then transferred back for further rehabilitation. Author comment: "Here we present a case of linezolid toxicity in a patient

Journal

Reactions Weekly – Springer Journals

Published: Jun 2, 2018

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