Ann Hematol (2017) 96:1579–1581 DOI 10.1007/s00277-017-3050-6 LETTER TO THE EDITOR Lineage switch from B acute lymphoblastic leukemia to acute monocytic leukemia with persistent t(4;11)(q21;q23) and cytogenetic evolution under CD19-targeted therapy 1 2 1 2 Estelle Balducci & Vanessa Nivaggioni & John Boudjarane & Lakhdar Bouriche & 3 2 1 4 4 Ilhem Rahal & Denis Bernot & Emilie Alazard & Nicolas Duployez & Nathalie Grardel & 2 1 3 5 Isabelle Arnoux & Marina Lafage-Pochitaloff & Gérard Michel & Bertrand Nadel & Marie Loosveld Received: 3 April 2017 /Accepted: 11 June 2017 /Published online: 20 June 2017 Springer-Verlag GmbH Germany 2017 Dear Editor, day 8 to day 29 according to the RIALTO protocol. At day 28, We here report a case of B-acute lymphoblastic leukemia BM aspirate revealed monocytic blasts (Fig. 1b) positive for (ALL) with KMT2A rearrangement that underwent a lineage CD33 (low), CD65 and CD15 and negative for B lineage switch to acute monocytic leukemia following CD19-targeted markers (cCD79a, CD19, CD22, CD34) (Fig. 1d, yellow). therapy. A 15-year-old male patient presented with leukocyto- Review of flow cytometry analysis prior to blinatumomab sis (white blood cells, 210 × 10 /L, anemia (hemoglobin, treatment demonstrated no monocytic subclones (with
Annals of Hematology – Springer Journals
Published: Jun 20, 2017
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