Limitations of Rb-82 weight-adjusted dosing accuracy at low doses

Limitations of Rb-82 weight-adjusted dosing accuracy at low doses BRIEF REPORT Limitations of Rb-82 weight-adjusted dosing accuracy at low doses a b Jonathan B. Moody, PhD, Kerri M. Hiller, BS, CNMT, RT(N), a b a,b Benjamin C. Lee, PhD, James R. Corbett, MD, Edward P. Ficaro, PhD, and Venkatesh L. Murthy, MD, PhD INVIA Medical Imaging Solutions, Ann Arbor, MI Division of Nuclear Medicine, Department of Radiology, University of Michigan, Ann Arbor, MI Received Dec 18, 2015; accepted Apr 28, 2016 doi:10.1007/s12350-016-0531-2 Introduction. Weight-adjusted dosing is important to maintain accurate quantification for dynamic cardiac three-dimensional positron emission tomography (PET). However, the man- ufacturer of the only Food and Drug Administration approved rubidium-82 (Rb-82) generator (CardioGen-82, Bracco Diagnostics, Inc.) recommends recalibration after each change in dose which is inefficient in a busy clinical PET lab. The objective of this study was to evaluate the accuracy of Rb-82 dosing without this recalibration. Methods. After daily calibration to either 30 mCi (1110 MBq) or 12 mCi (444 MBq), Rb- 82 doses between 6 and 45 mCi (222-1665 MBq) were eluted and measured on an external dose calibrator. This was repeated for four generators at weeks 1, 2, or 4 of the generator cycle. The measurements were compared with values reported by Journal of Nuclear Cardiology Springer Journals

Limitations of Rb-82 weight-adjusted dosing accuracy at low doses

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Copyright © 2016 by American Society of Nuclear Cardiology
Medicine & Public Health; Cardiology; Nuclear Medicine; Imaging / Radiology
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