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Lewis x Antigen is Associated to Head and Neck Squamous Cell Carcinoma Survival

Lewis x Antigen is Associated to Head and Neck Squamous Cell Carcinoma Survival Head and neck squamous cell carcinoma (HNSCC) is an aggressive disease with poor prognosis without appropriate prognostic markers. Previous research shows that Lewis antigens have been involved in carcinoma dissemination and patients´ survival. Fucosyl and sialyltransferases are the enzymes implicated in the Lewis antigens synthesis. The purpose of this study was to evaluate the prognostic utility of Lewis antigens in HNSCC. We conducted a prospective research including histological samples from 79 patients with primary HNSCC. Lewis x and sialyl Lewis x expression were detected by immunohistochemistry; patient’s data, progression free, and overall survival were documented. A statistical correlation study of antigenic expression and patients´ histopathological variables was performed. Cox regression models with internal validation procedures were employed to analyze survival data. By immunohistochemistry, Lewis x was detected in 34/79 (43%) tumor samples, while sialyl Lewis x only in 11/79 (14%). Lewis x expression showed a positive correlation with tumor differentiation and a better overall survival for Lewis x + patients was detected. Moreover, multivariate Cox’s regression analysis showed that Lewis x is an independent predictor of better overall survival. The in silico analysis supported the presence of deregulated fucosyl (FUT4) and sialyltransferase (ST3GAL4) in the Lewis synthetic pathway related to patient survival. These results suggest that Lewis x expression is associated with a better outcome in patients with HNSCC. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pathology & Oncology Research Springer Journals

Lewis x Antigen is Associated to Head and Neck Squamous Cell Carcinoma Survival

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Publisher
Springer Journals
Copyright
Copyright © 2017 by Arányi Lajos Foundation
Subject
Biomedicine; Cancer Research; Oncology; Pathology; Immunology; Biomedicine, general
ISSN
1219-4956
eISSN
1532-2807
DOI
10.1007/s12253-017-0269-4
pmid
28681122
Publisher site
See Article on Publisher Site

Abstract

Head and neck squamous cell carcinoma (HNSCC) is an aggressive disease with poor prognosis without appropriate prognostic markers. Previous research shows that Lewis antigens have been involved in carcinoma dissemination and patients´ survival. Fucosyl and sialyltransferases are the enzymes implicated in the Lewis antigens synthesis. The purpose of this study was to evaluate the prognostic utility of Lewis antigens in HNSCC. We conducted a prospective research including histological samples from 79 patients with primary HNSCC. Lewis x and sialyl Lewis x expression were detected by immunohistochemistry; patient’s data, progression free, and overall survival were documented. A statistical correlation study of antigenic expression and patients´ histopathological variables was performed. Cox regression models with internal validation procedures were employed to analyze survival data. By immunohistochemistry, Lewis x was detected in 34/79 (43%) tumor samples, while sialyl Lewis x only in 11/79 (14%). Lewis x expression showed a positive correlation with tumor differentiation and a better overall survival for Lewis x + patients was detected. Moreover, multivariate Cox’s regression analysis showed that Lewis x is an independent predictor of better overall survival. The in silico analysis supported the presence of deregulated fucosyl (FUT4) and sialyltransferase (ST3GAL4) in the Lewis synthetic pathway related to patient survival. These results suggest that Lewis x expression is associated with a better outcome in patients with HNSCC.

Journal

Pathology & Oncology Research – Springer Journals

Published: Jul 5, 2017

References

  • Interaction between tobacco and alcohol use and the risk of head and neck cancer: pooled analysis in the International head and neck cancer epidemiology consortium
    Hashibe, M; Brennan, P; Chuang, S-C
  • Human papillomavirus and oral cancer: the International Agency for Research on Cancer multicenter study
    Herrero, R; Castellsagué, X; Pawlita, M
  • 25 year survival outcomes for squamous cell carcinomas of the head and neck: population-based outcomes from a Canadian province
    Tiwana, MS; Wu, J; Hay, J; Wong, F; Cheung, W; Olson, RA
  • Prognostic factors for survival and tumor control in cervical lymph node metastases from head and neck cancer: a multivariate study of 492 cases
    Cerezo, L; Millan, I; Torre, A; Aragon, G; Otero, J
  • Carbohydrates in oral epithelia and secretions: variation with cellular differentiation
    Mandel, U
  • Aberrant glycosylation in tumors and tumor-associated carbohydrate antigens
    Hakomori, S
  • ABO blood-group antigens in oral cancer
    Dabelsteen, E; Gao, S
  • Contribution of carbohydrate antigens sialyl Lewis a and sialyl Lewis X to adhesion of human cancer cells to vascular endothelium
    Takada, A; Ohmori, K; Yoneda, T
  • Aberrant expression of mucin core proteins and o-linked glycans associated with progression of pancreatic cancer
    Remmers, N; Anderson, JM; Linde, EM
  • Patterns of MUC1 tissue expression defined by an anti-MUC1 cytoplasmic tail monoclonal antibody in breast cancer
    Croce, MV; Isla-Larrain, MT; Rua, CE; Rabassa, ME; Gendler, SJ; Segal-Eiras, A
  • Differential expression of MUC1 and carbohydrate antigens in primary and secondary head and neck squamous cell carcinoma
    Croce, MV; Rabassa, ME; Pereyra, A; Segal-Eiras, A
  • MUC1 expression and anti-MUC1 serum immune response in head and neck squamous cell carcinoma (HNSCC): a multivariate analysis
    Rabassa, ME; Croce, MV; Pereyra, A; Segal-Eiras, A
  • Influence of sialic acid removal on MUC1 antigenic reactivity in head and neck carcinoma
    Croce, MV; Rabassa, ME; Pereyra, A; Segal-Eiras, A
  • MUC1 mucin and carbohydrate associated antigens as tumor markers in head and neck squamous cell carcinoma
    Croce, MV; Rabassa, ME; Price, MR; Segal-Eiras, A
  • Identification of sialyl Lewis-x in squamous cell carcinoma of the head and neck
    Farmer, RW; Richtsmeier, WJ; Scher, RL
  • Immunohistochemical study of sialyl lea and sialyl le(x) antigen in oral squamous cell carcinoma: the association of sialyl lea expression with the metastatic potential
    Kurahara, SI; Shinohara, M; Ikebe, T
  • E-cadherin truncation and sialyl Lewis-X overexpression in oral squamous cell carcinoma and oral precancerous conditions
    Shah, MH; Sainger, RN; Telang, SD; Pancholi, GH; Shukla, SN; Patel, PS
  • Prognostic molecular markers in head and neck squamous cell carcinoma in a New Zealand population: matrix metalloproteinase-2 and sialyl Lewis x antigen
    Gunawardena, I; Arendse, M; Jameson, MB; Plank, LD; Gregor, RT
  • Immunohistochemical localization of Leu-M1 carbohydrate antigen in human oral squamous cell carcinoma
    Teng, YT; Nadimi, H; Toto, PD
  • Lex and related structures as adhesion molecules
    Hakomori, SI
  • Stage-specific expression of alpha1,2-fucosyltransferase and alpha1, 3-fucosyltransferase (FT) during mouse embryogenesis
    Liu, N; Jin, C; Zhu, ZM
  • Lewis x is highly expressed in normal tissues: a comparative immunohistochemical study and literature revision
    Croce, MV; Isla-Larrain, M; Rabassa, ME; Demichelis, S; Colussi, AG; Crespo, M
  • Expression of the CD15 antigen on normal and leukemic myeloid cells: effects of neuraminidase and variable detection with a panel of monoclonal antibodies
    Ball, ED; Schwarz, LM; Bloomfield, CD
  • Expression of Lewis X is associated with poor prognosis in triple-negative breast cancer
    Koh, YW; Lee, HJ; Ahn, J-H; Lee, JW; Gong, G
  • Expression patterns of CD33 and CD15 predict outcome in patients with acute myeloid leukemia
    Derolf, AR; Björklund, E; Mazur, J; Björkholm, M; Porwit, A
  • Reporting recommendations for tumor marker prognostic studies (REMARK): explanation and elaboration
    Altman, DG; McShane, LM; Sauerbrei, W; Taube, SE
  • Expression of cell surface Lewis X and Y antigens and FUT4 mRNA is increased in Jurkat cells undergoing apoptosis
    Azuma, Y; Ito, M; Taniguchi, A; Matsumoto, K
  • Relevance of βGal-βGalNAc-containing glycans and the enzymes involved in their synthesis for invasion and survival in breast cancer patients
    Milde-Langosch, K; Schütze, D; Oliveira-Ferrer, L
  • FISH characterization of head and neck carcinomas reveals that amplification of band 11q13 is associated with deletion of distal 11q
    Jin, Y; Höglund, M; Jin, C
  • ST3Gal-4 is the primary sialyltransferase regulating the synthesis of E-, P-, and L-selectin ligands on human myeloid leukocytes
    Mondal, N; Buffone, A; Stolfa, G
  • Altered mRNA expression of specific molecular species of fucosyl- and sialyl-transferases in human colorectal cancer tissues
    Ito, H; Hiraiwa, N; Sawada-Kasugai, M
  • Up-regulation of a set of glycosyltransferase genes in human colorectal cancer
    Kudo, T; Ikehara, Y; Togayachi, A
  • Fucosylation in prokaryotes and eukaryotes
    Ma, B; Simala-Grant, JL; Taylor, DE
  • FUT4 and FUT9 genes are expressed early in human embryogenesis
    Cailleau-Thomas, A; Coullin, P; Candelier, JJ
  • Transcriptional regulation of human beta-galactoside alpha2, 6-sialyltransferase (hST6Gal I) gene during differentiation of the HL-60 cell line
    Taniguchi, A; Hasegawa, Y; Higai, K; Matsumoto, K
  • Selectin ligand sialyl-Lewis x antigen drives metastasis of hormone-dependent breast cancers
    Julien, S; Ivetic, A; Grigoriadis, A
  • Suppression of FUT1/FUT4 expression by siRNA inhibits tumor growth
    Zhang, Z; Sun, P; Liu, J
  • Sialylation and fucosylation of epidermal growth factor receptor suppress its dimerization and activation in lung cancer cells
    Liu, Y-C; Yen, H-Y; Chen, C-Y