Levonorgestrel

Levonorgestrel Reactions 1704, p226 - 2 Jun 2018 Anembryonic pregnancy following contraceptive failure : case report A 31-year-old woman developed anembryonic pregnancy following failure of levonorgestrel subdermal implant [Jadelle; dosage not stated]. The woman with a subdermal implant in her left arm for 13 months, presented to hospital eight weeks and one day after her last normal menstrual period (T0+8 weeks 1 day)with complaints of pelvic pain, prolonged menstrual bleeding and spotting of 1 month duration. The pain was insidious, cramping, had no aggravating or relieving factors. Two weeks after the symptoms appeared (T0+6 weeks 1 day), she consulted at a local health centre where a beta-human chorionic gonadotrophin (hCG) qualitative urine pregnancy test was found negative. The symptoms were considered as adverse reactions of levonorgestrel, and she was prescribed paracetamol tablets. However, due to persisting symptoms, she presented for the current presentation. Her physical examination, showed suprapubic tenderness and blood trickling from her cervix was noted in speculum vaginal examination. Pelvic ultrasound demonstrated an intrauterine gestational sac with mean gestational sac diameter (MSD) of 28mm without any yolk sac. Subsequently, she was diagnosed with an anembryonic pregnancy secondary implant failure at 8 weeks 1 day gestational age (based on last menstrual period). The woman underwent dilatation and curettage with suction the following day under local anaesthesia, with aid of a manual vacuum aspirator. She was monitored for 6 hours and discharged home. During a follow-up examination after five days, she reported resolution of the pelvic pain and vaginal bleeding. Physical examination of abdomen and speculum vaginal examination were normal. Author comment: "In this case report, we describe a rare incident of anembryonic pregnancy following failed contraception with 13 months’ regular JADELLE implant use." Moutchia-Suh J, et al. Occurrence of anembryonic pregnancy with use of levonorgestrel subdermal implant (JADELLE): A case report. Journal of Medical Case Reports 12: 111, No. 1, 2018. Available from: URL: http://doi.org/10.1186/ s13256-018-1675-2 - Cameroon 803322995 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Levonorgestrel

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018
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Publisher
Springer International Publishing
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-018-46869-2
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p226 - 2 Jun 2018 Anembryonic pregnancy following contraceptive failure : case report A 31-year-old woman developed anembryonic pregnancy following failure of levonorgestrel subdermal implant [Jadelle; dosage not stated]. The woman with a subdermal implant in her left arm for 13 months, presented to hospital eight weeks and one day after her last normal menstrual period (T0+8 weeks 1 day)with complaints of pelvic pain, prolonged menstrual bleeding and spotting of 1 month duration. The pain was insidious, cramping, had no aggravating or relieving factors. Two weeks after the symptoms appeared (T0+6 weeks 1 day), she consulted at a local health centre where a beta-human chorionic gonadotrophin (hCG) qualitative urine pregnancy test was found negative. The symptoms were considered as adverse reactions of levonorgestrel, and she was prescribed paracetamol tablets. However, due to persisting symptoms, she presented for the current presentation. Her physical examination, showed suprapubic tenderness and blood trickling from her cervix was noted in speculum vaginal examination. Pelvic ultrasound demonstrated an intrauterine gestational sac with mean gestational sac diameter (MSD) of 28mm without any yolk sac. Subsequently, she was diagnosed with an anembryonic pregnancy secondary implant failure at 8 weeks 1 day gestational age (based on last menstrual period). The woman underwent dilatation and curettage with suction the following day under local anaesthesia, with aid of a manual vacuum aspirator. She was monitored for 6 hours and discharged home. During a follow-up examination after five days, she reported resolution of the pelvic pain and vaginal bleeding. Physical examination of abdomen and speculum vaginal examination were normal. Author comment: "In this case report, we describe a rare incident of anembryonic pregnancy following failed contraception with 13 months’ regular JADELLE implant use." Moutchia-Suh J, et al. Occurrence of anembryonic pregnancy with use of levonorgestrel subdermal implant (JADELLE): A case report. Journal of Medical Case Reports 12: 111, No. 1, 2018. Available from: URL: http://doi.org/10.1186/ s13256-018-1675-2 - Cameroon 803322995 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704

Journal

Reactions WeeklySpringer Journals

Published: Jun 2, 2018

References

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