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Levodopa

Levodopa Reactions 1704, p224 - 2 Jun 2018 Dyskinesias: 14 case reports In a study, 14 patients [ages and sexes not stated] developed dyskinesias during treatment with levodopa for Parkinson’s disease [dosages, routes and durations of treatments to reactions onsets not stated]. The patients were diagnosed with Parkinson’s disease and started receiving levodopa. Subsequently, the patients developed drug-induced dyskinesias (DID). Total duration of the DID was reported as 10 17 hours. The patients subsequently underwent a postero-ventral pallidotomy (PVP). An improvement in the dyskinesias was reported post-operatively. The daily dose of levodopa was reduced by 15% after the surgery, in 50% of the patients. However, the levodopa dose returned to the preoperative values six months after the surgery. Following six months of the surgery, the DID was found to be improved to 2 8 hours. Author comment: Lengthy pharmacotherapy of Parkinson’s disease (PD) leads already after 3 5 years of taking levodopa to the development of side effects in the form of various motor fluctuations and drug-induced dyskinesias (DID), which become an independent desadaptative factor that impacts the patient’s daily life activities. In our study, drug-induced dyskinesias after a unilateral PVP regressed on average by 68.3 ± 9.7% contraleterally and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Levodopa

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018

Levodopa

Abstract

Reactions 1704, p224 - 2 Jun 2018 Dyskinesias: 14 case reports In a study, 14 patients [ages and sexes not stated] developed dyskinesias during treatment with levodopa for Parkinson’s disease [dosages, routes and durations of treatments to reactions onsets not stated]. The patients were diagnosed with Parkinson’s disease and started receiving levodopa. Subsequently, the patients developed drug-induced dyskinesias (DID). Total duration of the DID was reported as 10 17 hours. The...
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References (1)

Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
DOI
10.1007/s40278-018-46867-2
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p224 - 2 Jun 2018 Dyskinesias: 14 case reports In a study, 14 patients [ages and sexes not stated] developed dyskinesias during treatment with levodopa for Parkinson’s disease [dosages, routes and durations of treatments to reactions onsets not stated]. The patients were diagnosed with Parkinson’s disease and started receiving levodopa. Subsequently, the patients developed drug-induced dyskinesias (DID). Total duration of the DID was reported as 10 17 hours. The patients subsequently underwent a postero-ventral pallidotomy (PVP). An improvement in the dyskinesias was reported post-operatively. The daily dose of levodopa was reduced by 15% after the surgery, in 50% of the patients. However, the levodopa dose returned to the preoperative values six months after the surgery. Following six months of the surgery, the DID was found to be improved to 2 8 hours. Author comment: Lengthy pharmacotherapy of Parkinson’s disease (PD) leads already after 3 5 years of taking levodopa to the development of side effects in the form of various motor fluctuations and drug-induced dyskinesias (DID), which become an independent desadaptative factor that impacts the patient’s daily life activities. In our study, drug-induced dyskinesias after a unilateral PVP regressed on average by 68.3 ± 9.7% contraleterally and

Journal

Reactions WeeklySpringer Journals

Published: Jun 2, 2018

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