Levodopa

Levodopa Reactions 1704, p224 - 2 Jun 2018 Dyskinesias: 14 case reports In a study, 14 patients [ages and sexes not stated] developed dyskinesias during treatment with levodopa for Parkinson’s disease [dosages, routes and durations of treatments to reactions onsets not stated]. The patients were diagnosed with Parkinson’s disease and started receiving levodopa. Subsequently, the patients developed drug-induced dyskinesias (DID). Total duration of the DID was reported as 10 17 hours. The patients subsequently underwent a postero-ventral pallidotomy (PVP). An improvement in the dyskinesias was reported post-operatively. The daily dose of levodopa was reduced by 15% after the surgery, in 50% of the patients. However, the levodopa dose returned to the preoperative values six months after the surgery. Following six months of the surgery, the DID was found to be improved to 2 8 hours. Author comment: Lengthy pharmacotherapy of Parkinson’s disease (PD) leads already after 3 5 years of taking levodopa to the development of side effects in the form of various motor fluctuations and drug-induced dyskinesias (DID), which become an independent desadaptative factor that impacts the patient’s daily life activities. In our study, drug-induced dyskinesias after a unilateral PVP regressed on average by 68.3 ± 9.7% contraleterally and by 50% ipsilaterally. Tyurnikov VM, et al. Unilateral posteroventral pallidotomy in the treatment of drug-induced dyskinesia in Parkinson’s disease. Zhurnal Voprosy Neirokhirurgii Imeni N. N. Burdenko 81: 69-75, No. 5, 2017. Available from: URL: http:// doi.org/10.17116/neiro201781569-74 [Russian; summarised from a translation] - Russia 803322710 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Levodopa

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018
Free
1 page

Loading next page...
1 Page
 
/lp/springer_journal/levodopa-080QCXlOyE
Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-018-46867-2
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p224 - 2 Jun 2018 Dyskinesias: 14 case reports In a study, 14 patients [ages and sexes not stated] developed dyskinesias during treatment with levodopa for Parkinson’s disease [dosages, routes and durations of treatments to reactions onsets not stated]. The patients were diagnosed with Parkinson’s disease and started receiving levodopa. Subsequently, the patients developed drug-induced dyskinesias (DID). Total duration of the DID was reported as 10 17 hours. The patients subsequently underwent a postero-ventral pallidotomy (PVP). An improvement in the dyskinesias was reported post-operatively. The daily dose of levodopa was reduced by 15% after the surgery, in 50% of the patients. However, the levodopa dose returned to the preoperative values six months after the surgery. Following six months of the surgery, the DID was found to be improved to 2 8 hours. Author comment: Lengthy pharmacotherapy of Parkinson’s disease (PD) leads already after 3 5 years of taking levodopa to the development of side effects in the form of various motor fluctuations and drug-induced dyskinesias (DID), which become an independent desadaptative factor that impacts the patient’s daily life activities. In our study, drug-induced dyskinesias after a unilateral PVP regressed on average by 68.3 ± 9.7% contraleterally and by 50% ipsilaterally. Tyurnikov VM, et al. Unilateral posteroventral pallidotomy in the treatment of drug-induced dyskinesia in Parkinson’s disease. Zhurnal Voprosy Neirokhirurgii Imeni N. N. Burdenko 81: 69-75, No. 5, 2017. Available from: URL: http:// doi.org/10.17116/neiro201781569-74 [Russian; summarised from a translation] - Russia 803322710 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704

Journal

Reactions WeeklySpringer Journals

Published: Jun 2, 2018

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off