Eur Arch Otorhinolaryngol (2017) 274:3541 DOI 10.1007/s00405-017-4495-x LETTER TO THE EDITOR Letter to the editor on “The therapeutic effect of thymoquinone on acoustic trauma-induced hearing loss in rats” 1 1 1 Alper Yenigun · Remzi Dogan · Orhan Ozturan Received: 2 January 2017 / Accepted: 3 February 2017 / Published online: 13 March 2017 © Springer-Verlag Berlin Heidelberg 2017 Dear Editor, The other point is that AbuKhader has reported in his paper that maximum tolerated dose of TQ that is applied I came across to the article titled “The therapeutic effect through i.p. is 22.5 mg/kg for male rats . In this study, of thymoquinone on acoustic trauma-induced hearing loss they used 20 and 40 mg/kg of TQ i.p. and they did not per- in rats” by Mahmut Ogurlu et al. which was published in form any biochemical tests to examine the toxicity of TQ. your journal , and this article cited our study  in their Finally, the authors have concluded that their study is the manuscript. The article is well written and I appreciate the second study showing the reparative effect of TQ in trauma effort of the authors. However, it provokes some contro- acoustic-induced hearing loss. They also emphasized that versy, which I would like to highlight. 20 mg/kg is sufficient and higher doses are not needed. First, the authors have mentioned our study in discussion We demonstrated in our study that 10 mg/kg of TQ is suf- part of their article by “They used 10 mg/kg of i.p. TQ, ficient for full recovery of acoustic trauma . It was also which is lower than our study dose. It should be noted that shown that more than 22.5 mg/kg is toxic in rats . Thus, despite a treatment for 10 days, their post-treatment results we agree with the authors that using higher doses of TQ in were not as good as their pre-trauma results. This may indi- the treatment of acoustic trauma on rats is not needed and cate that 10 mg/kg is not a sufficient dose for full recov - 10 mg/kg has already given sufficient results. We wait for ery after acoustic trauma” . We believe that the authors the author’s contribution and opinion. have misinterpreted our results. In our study, thymoqui- Compliance with ethical standards none (TQ) administration was started 1 day before acoustic trauma and was continued for 10 days. It was administered Conflict of interest All authors declare that they have no conflict intraperitoneally at a dose of 10 mg/kg/day . We dem- of interest. onstrated that 10 mg/kg ip TQ was sufficient, since ABR and DPOAE results at the fifth and tenth days of treatment were similar to pre-trauma measurements demonstrating its References reparative effect . 1. Ogurlu M, Erdivanli OC, Tumkaya L, Ozgur A, Ozergin Coskun Z, Terzi S, Demirci M, Dursun E (2017) The therapeutic effect This comment refers to the article available at doi:10.1007/ of thymoquinone on acoustic trauma-induced hearing loss in s00405-016-4319-4. rats. Eur Arch Otorhinolaryngol 274(2):743–749 2. Aksoy F, Dogan R, Yenigun A, Veyseller B, Ozturan O, Ozturk An author’s reply to this comment is available at doi:10.1007/ B (2015) Thymoquinone treatment for inner-ear acoustic trauma s00405-017-4499-6. in rats. J Laryngol Otol 129(1):38–45 3. Abukhader MM (2012) The effect of route of administration in * Alper Yenigun thymoquinone toxicity in male and female rats. Indian J Pharm firstname.lastname@example.org Sci 74(3):195–200 Department of Otorhinolaryngology, Faculty of Medicine, Bezmialem Vakif University, Adnan Menderes Bulvarı Vatan Caddesi, Fatih, 34093 Istanbul, Turkey Vol.:(0123456789) 1 3
European Archives of Oto-Rhino-Laryngology – Springer Journals
Published: Mar 13, 2017
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
All the latest content is available, no embargo periods.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud