Eur Arch Otorhinolaryngol (2017) 274:3541 DOI 10.1007/s00405-017-4495-x LETTER TO THE EDITOR Letter to the editor on “The therapeutic effect of thymoquinone on acoustic trauma-induced hearing loss in rats” 1 1 1 Alper Yenigun · Remzi Dogan · Orhan Ozturan Received: 2 January 2017 / Accepted: 3 February 2017 / Published online: 13 March 2017 © Springer-Verlag Berlin Heidelberg 2017 Dear Editor, The other point is that AbuKhader has reported in his paper that maximum tolerated dose of TQ that is applied I came across to the article titled “The therapeutic effect through i.p. is 22.5 mg/kg for male rats . In this study, of thymoquinone on acoustic trauma-induced hearing loss they used 20 and 40 mg/kg of TQ i.p. and they did not per- in rats” by Mahmut Ogurlu et al. which was published in form any biochemical tests to examine the toxicity of TQ. your journal , and this article cited our study  in their Finally, the authors have concluded that their study is the manuscript. The article is well written and I appreciate the second study showing the reparative effect of TQ in trauma effort of the authors. However, it provokes some contro- acoustic-induced hearing loss. They also emphasized that versy, which I would like to highlight. 20 mg/kg is sufficient and higher doses are not needed. First, the authors have mentioned our study in discussion We demonstrated in our study that 10 mg/kg of TQ is suf- part of their article by “They used 10 mg/kg of i.p. TQ, ficient for full recovery of acoustic trauma . It was also which is lower than our study dose. It should be noted that shown that more than 22.5 mg/kg is toxic in rats . Thus, despite a treatment for 10 days, their post-treatment results we agree with the authors that using higher doses of TQ in were not as good as their pre-trauma results. This may indi- the treatment of acoustic trauma on rats is not needed and cate that 10 mg/kg is not a sufficient dose for full recov - 10 mg/kg has already given sufficient results. We wait for ery after acoustic trauma” . We believe that the authors the author’s contribution and opinion. have misinterpreted our results. In our study, thymoqui- Compliance with ethical standards none (TQ) administration was started 1 day before acoustic trauma and was continued for 10 days. It was administered Conflict of interest All authors declare that they have no conflict intraperitoneally at a dose of 10 mg/kg/day . We dem- of interest. onstrated that 10 mg/kg ip TQ was sufficient, since ABR and DPOAE results at the fifth and tenth days of treatment were similar to pre-trauma measurements demonstrating its References reparative effect . 1. Ogurlu M, Erdivanli OC, Tumkaya L, Ozgur A, Ozergin Coskun Z, Terzi S, Demirci M, Dursun E (2017) The therapeutic effect This comment refers to the article available at doi:10.1007/ of thymoquinone on acoustic trauma-induced hearing loss in s00405-016-4319-4. rats. Eur Arch Otorhinolaryngol 274(2):743–749 2. Aksoy F, Dogan R, Yenigun A, Veyseller B, Ozturan O, Ozturk An author’s reply to this comment is available at doi:10.1007/ B (2015) Thymoquinone treatment for inner-ear acoustic trauma s00405-017-4499-6. in rats. J Laryngol Otol 129(1):38–45 3. Abukhader MM (2012) The effect of route of administration in * Alper Yenigun thymoquinone toxicity in male and female rats. Indian J Pharm email@example.com Sci 74(3):195–200 Department of Otorhinolaryngology, Faculty of Medicine, Bezmialem Vakif University, Adnan Menderes Bulvarı Vatan Caddesi, Fatih, 34093 Istanbul, Turkey Vol.:(0123456789) 1 3
European Archives of Oto-Rhino-Laryngology – Springer Journals
Published: Mar 13, 2017
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