Letter to the Editor: Implications of BRAF Mutations in dMMR Colorectal Cancers

Letter to the Editor: Implications of BRAF Mutations in dMMR Colorectal Cancers Curr. Treat. Options in Oncol. (2017) 18:57 DOI 10.1007/s11864-017-0493-x Letter to the Editor Letter to the Editor: Implications of BRAF Mutations in dMMR Colorectal Cancers Steven Sorscher, MD Address Wake Forest School of Medicine, Oncology Division, Medical Center Blvd, Winston- Salem, NC, 27157, USA Email: ssorsche@wakehealth.edu * Springer Science+Business Media, LLC 2017 This comment refers to the article available at http://dx.doi.org/10.1007/s11864-017-0453-5 Keywords dMMR BRAF Checkpoint I I Dear Editor, I appreciated the recently published “BRAF-Mutated Colorectal Cancer: What is the Optimal Strategy for Treatments?” [1]. The authors appropriately note that immune checkpoint inhibitor therapy has shown very promising results for patients with tumors harboring dMMR. They suggest that such therapy might prove effective for patients with dMMR associated with a BRAF mutation but support this possibility with two references, one that did not distinguish response rates between pa- tients with dMMR tumors associated with a BRAF mutation and those not associated with a BRAF mutation. For the second reference (an abstract concerning an ongoing study), they note “clinical activity was observed regardless of the BRAF and KRAS mutational status mutational statuses and PDL-1 expression.” However, the 25% investigator-determined re- sponse rate apparently involved responses in just three patients with http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Treatment Options in Oncology Springer Journals

Letter to the Editor: Implications of BRAF Mutations in dMMR Colorectal Cancers

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Medicine & Public Health; Oncology
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