Letter to the Editor: Implications of BRAF Mutations in dMMR Colorectal Cancers

Letter to the Editor: Implications of BRAF Mutations in dMMR Colorectal Cancers Curr. Treat. Options in Oncol. (2017) 18: 57 DOI 10.1007/s11864-017-0493-x Letter to the Editor Letter to the Editor: Implications of BRAF Mutations in dMMR Colorectal Cancers Steven Sorscher, MD Address Wake Forest School of Medicine, Oncology Division, Medical Center Blvd, Winston- Salem, NC, 27157, USA Email: ssorsche@wakehealth.edu Published online: 10 August 2017 * Springer Science+Business Media, LLC 2017 This comment refers to the article available at http://dx.doi.org/10.1007/s11864-017-0453-5 Keywords dMMR BRAF Checkpoint I I Dear Editor, I appreciated the recently published “BRAF-Mutated Colorectal Cancer: What is the Optimal Strategy for Treatments?” [1]. The authors appropriately note that immune checkpoint inhibitor therapy has shown very promising results for patients with tumors harboring dMMR. They suggest that such therapy might prove effective for patients with dMMR associated with a BRAF mutation but support this possibility with two references, one that did not distinguish response rates between pa- tients with dMMR tumors associated with a BRAF mutation and those not associated with a BRAF mutation. For the second reference (an abstract concerning an ongoing study), they note “clinical activity was observed regardless of the BRAF and KRAS mutational status mutational statuses and PDL-1 expression.” However, the 25% investigator-determined re- sponse rate apparently involved http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Treatment Options in Oncology Springer Journals

Letter to the Editor: Implications of BRAF Mutations in dMMR Colorectal Cancers

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Publisher
Springer US
Copyright
Copyright © 2017 by Springer Science+Business Media, LLC
Subject
Medicine & Public Health; Oncology
ISSN
1527-2729
eISSN
1534-6277
D.O.I.
10.1007/s11864-017-0493-x
Publisher site
See Article on Publisher Site

Abstract

Curr. Treat. Options in Oncol. (2017) 18: 57 DOI 10.1007/s11864-017-0493-x Letter to the Editor Letter to the Editor: Implications of BRAF Mutations in dMMR Colorectal Cancers Steven Sorscher, MD Address Wake Forest School of Medicine, Oncology Division, Medical Center Blvd, Winston- Salem, NC, 27157, USA Email: ssorsche@wakehealth.edu Published online: 10 August 2017 * Springer Science+Business Media, LLC 2017 This comment refers to the article available at http://dx.doi.org/10.1007/s11864-017-0453-5 Keywords dMMR BRAF Checkpoint I I Dear Editor, I appreciated the recently published “BRAF-Mutated Colorectal Cancer: What is the Optimal Strategy for Treatments?” [1]. The authors appropriately note that immune checkpoint inhibitor therapy has shown very promising results for patients with tumors harboring dMMR. They suggest that such therapy might prove effective for patients with dMMR associated with a BRAF mutation but support this possibility with two references, one that did not distinguish response rates between pa- tients with dMMR tumors associated with a BRAF mutation and those not associated with a BRAF mutation. For the second reference (an abstract concerning an ongoing study), they note “clinical activity was observed regardless of the BRAF and KRAS mutational status mutational statuses and PDL-1 expression.” However, the 25% investigator-determined re- sponse rate apparently involved

Journal

Current Treatment Options in OncologySpringer Journals

Published: Aug 10, 2017

References

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