Leptin receptor mutations in 129 db 3J/db3.J mice and NIH fa cp/facp rats

Leptin receptor mutations in 129 db 3J/db3.J mice and NIH fa cp/facp rats Mammalian Genome 8,445-447 (1997). ~.enome 9 Springer-Verlag New York Inc. 1997 Leptin receptor mutations in 129 db3J/db 3J mice and NIH faCl'/fa cp rats G.-H. Lee, 1'2 C. Li, 1'2 J. Montez, 1 J. Halaas, 1 J. Darvishzadeh, 1'2 J.M. Friedman 1'2 ~Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, Box 305, New York, NY 10021, USA 2Laboratory of Molecular Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA Received: 23 November 1996 / Accepted: 31 January 1997 The cloning of leptin and its receptor have led to the identification total RNA was used as a template to synthesize eDNA with Mo- of a novel signal transduction pathway important in body weight MuLV reverse transcriptase according to the manufacturer's rec- regulation (Zhang et al. 1994; Tartaglia et al. 1995; Lee et al. ommendations (Lee et al. 1996). Lepr DNA fragments were am- 1996). Previous data have indicated that the db gene encodes sev- plified with eDNA or genomic DNA from mutant and wild-type eral alternatively spliced forms of the receptor for the ob gene animals with Taq DNA polymerase and primers based on the product, leptin (Tartaglia et al. 1995; Lee et al. 1996; http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Mammalian Genome Springer Journals

Leptin receptor mutations in 129 db 3J/db3.J mice and NIH fa cp/facp rats

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Publisher
Springer-Verlag
Copyright
Copyright © 1997 by Springer-Verlag
Subject
Life Sciences; Cell Biology; Anatomy; Zoology
ISSN
0938-8990
eISSN
1432-1777
D.O.I.
10.1007/s003359900466
Publisher site
See Article on Publisher Site

Abstract

Mammalian Genome 8,445-447 (1997). ~.enome 9 Springer-Verlag New York Inc. 1997 Leptin receptor mutations in 129 db3J/db 3J mice and NIH faCl'/fa cp rats G.-H. Lee, 1'2 C. Li, 1'2 J. Montez, 1 J. Halaas, 1 J. Darvishzadeh, 1'2 J.M. Friedman 1'2 ~Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, Box 305, New York, NY 10021, USA 2Laboratory of Molecular Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA Received: 23 November 1996 / Accepted: 31 January 1997 The cloning of leptin and its receptor have led to the identification total RNA was used as a template to synthesize eDNA with Mo- of a novel signal transduction pathway important in body weight MuLV reverse transcriptase according to the manufacturer's rec- regulation (Zhang et al. 1994; Tartaglia et al. 1995; Lee et al. ommendations (Lee et al. 1996). Lepr DNA fragments were am- 1996). Previous data have indicated that the db gene encodes sev- plified with eDNA or genomic DNA from mutant and wild-type eral alternatively spliced forms of the receptor for the ob gene animals with Taq DNA polymerase and primers based on the product, leptin (Tartaglia et al. 1995; Lee et al. 1996;

Journal

Mammalian GenomeSpringer Journals

Published: Mar 24, 2009

References

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