Mammalian Genome 8,445-447 (1997). ~.enome 9 Springer-Verlag New York Inc. 1997 Leptin receptor mutations in 129 db3J/db 3J mice and NIH faCl'/fa cp rats G.-H. Lee, 1'2 C. Li, 1'2 J. Montez, 1 J. Halaas, 1 J. Darvishzadeh, 1'2 J.M. Friedman 1'2 ~Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, Box 305, New York, NY 10021, USA 2Laboratory of Molecular Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA Received: 23 November 1996 / Accepted: 31 January 1997 The cloning of leptin and its receptor have led to the identification total RNA was used as a template to synthesize eDNA with Mo- of a novel signal transduction pathway important in body weight MuLV reverse transcriptase according to the manufacturer's rec- regulation (Zhang et al. 1994; Tartaglia et al. 1995; Lee et al. ommendations (Lee et al. 1996). Lepr DNA fragments were am- 1996). Previous data have indicated that the db gene encodes sev- plified with eDNA or genomic DNA from mutant and wild-type eral alternatively spliced forms of the receptor for the ob gene animals with Taq DNA polymerase and primers based on the product, leptin (Tartaglia et al. 1995; Lee et al. 1996;
Mammalian Genome – Springer Journals
Published: Mar 24, 2009
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