Lenalidomide Reactions 1680, p199 - 2 Dec 2017 Pulmonary embolism, deep vein thrombosis and cardiac arrest: case report In a retrospective study of clinical trial NCT02341781 (MCL-004 study), a 68-year-old man was described, who developed pulmonary embolism, deep vein thrombosis (DVT) and cardiac arrest during treatment with lenalidomide [IMid]. Subsequently, he died. The man, who had a history of mantle cell lymphoma, was started on oral lenalilomide [dosage not stated]. Two months after the start of the treatment, he had a partial response. However, 83 days after the first dose of lenalidomide, he died because of pulmonary embolism, which was suspected to be related to the lenalidomide. Additionally, he experienced grade five adverse events deep vein thrombosis and cardiac arrest. Author comment: "This patient had a (partial response) 2 months after lenalidomide initiation but died due to a pulmonary embolism, suspected to be related to lenalidomide therapy, as well as had incidences of other grade 5 AEs (DVT and cardiac arrest). " Wang M, et al. Observational study of lenalidomide in patients with mantle cell lymphoma who relapsed/progressed after or were refractory/intolerant to ibrutinib (MCL-004). Journal of Hematology and Oncology 10: 171, 2 Nov 2017. Available from: URL: http://doi.org/10.1186/s13045-017-0537-5 - USA 803284562 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals


Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Springer International Publishing
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
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