Leflunomide/methotrexate Reactions 1680, p198 - 2 Dec 2017 Hepatotoxicity and bone marrow suppression: 2 case reports In a study of 30 patients, two patients [ages and sexes not stated] were described, who developed hepatotoxicity and hepatotoxicity with bone marrow suppression, respectively during treatment with methotrexate and leflunomide. The patients, who had a history of rheumatoid arthritis, were undergoing treatment with methotrexate and leflunomide [routes and dosages not stated] and subsequently, one patient developed hepatotoxicity whereas, another patient developed hepatotoxicity with bone marrow suppression [times to reactions onsets not stated]. The patient’s methotrexate and leflunomide were stopped. The patients condition returned to normal within one month of methotrexate and leflunomide discontinuation. Author comment: "Many Rheumatologists worldwide are skeptical to use of this combination due to possible side effects like hepatotoxicity and bone marrow suppression." Doshi BS, et al. Study of efficacy and safety of methotrexate and leflunomide combination therapy in patients with rheumatoid arthritis (RA)- An audit. Indian Journal of Rheumatology 9 (Suppl.): S25-S26 abstr. P66, No. 5, Jul 2014. Available from: URL: http://doi.org/10.1016/j.injr.2014.10.005 [abstract] - India 803284784 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals


Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Springer International Publishing
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
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