J. Membrane Biol. 206, 75–83 (2005) DOI: 10.1007/s00232-005-0785-0 Learning how Membrane Fatty Acids Aﬀect Cardiovascular Integrity William E.M. Lands College Park, MD 20740, USA Received: 8 September 2005 Overview studying the saturated lung surfactant (dipalmitoyl lecithin) and the enigmatic plasmalogens (abundant The proportion of n-3 acids among the 20- and 22- in brain and heart tissue). The studies with lung tissue carbon highly unsaturated fatty acids (HUFA) of gave us early clues to enzymes that catalyze inde- tissues can vary from 20 to 80 percent depending on pendent turnover of acyl groups on the glycerol voluntary food choices of individuals. Such food ‘‘backbone’’ (Lands, 1958), and new knowledge of choices are the origin of essential n-3 and n-6 HUFA plasmalogen biochemistry let us make speciﬁc 2-acyl in the tissues of humans. This review describes how substrates for study of selective acyl chain transfer. my research on membrane lipids led me to believe Combining that knowledge with studies of venom that Americans should eat more n-3 (omega-3) and phospholipase let us prove that typical phospholipids less n-6 (omega-6) fats. The belief has roots from my had saturated acids selectively placed at the 1-posi- early studies in graduate school, which included
The Journal of Membrane Biology – Springer Journals
Published: Jan 1, 2005
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