Laryngeal Basaloid Squamous Cell Carcinoma with a Substantial Spindle Cell Component: Case Presentation and Updated Review of Literature

Laryngeal Basaloid Squamous Cell Carcinoma with a Substantial Spindle Cell Component: Case... Basaloid squamous cell carcinoma with spindle cell component is an uncommon aggressive variety of squamous cell car- cinoma with only a few reported cases in literature. Histologically a combination of basaloid squamous cell carcinoma and spindle cell squamous cell carcinoma is appreciated and immunohistochemistry serves a role in differentiation from malignant neoplasms of salivary gland or neuro-endocrine origin. Prime treatment modality is combination of surgery and external beam radiotherapy. A case of basaloid squamous cell carcinoma with proliferation of bizarre mesenchymal component is being reported here with an updated literature review. Keywords Basaloid · Epithelial mesenchymal transition · Glottis · Spindle cell Introduction Here, we report a glottic basaloid squamous cell carci- noma showing a substantial spindle cell component extend- Basaloid squamous cell carcinoma (BSCC) of the head and ing to sub-glottis and right pyriform sinus (hypopharynx) neck is considered to be an uncommon malignancy with an with emphasis on histological differential diagnosis and unfavorable clinical outcome. In 1986, Wain et al. reported review of literature. the first head and neck case [1 ]. In rare instances, a bipha- sic histological presentation comprising of basaloid squa- mous cell carcinoma with spindle cell component has been Case Presentation reported in various sites such as http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Head and Neck Pathology Springer Journals

Laryngeal Basaloid Squamous Cell Carcinoma with a Substantial Spindle Cell Component: Case Presentation and Updated Review of Literature

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Publisher
Springer US
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Medicine & Public Health; Pathology; Otorhinolaryngology; Oral and Maxillofacial Surgery; Dentistry
eISSN
1936-0568
D.O.I.
10.1007/s12105-018-0942-2
Publisher site
See Article on Publisher Site

Abstract

Basaloid squamous cell carcinoma with spindle cell component is an uncommon aggressive variety of squamous cell car- cinoma with only a few reported cases in literature. Histologically a combination of basaloid squamous cell carcinoma and spindle cell squamous cell carcinoma is appreciated and immunohistochemistry serves a role in differentiation from malignant neoplasms of salivary gland or neuro-endocrine origin. Prime treatment modality is combination of surgery and external beam radiotherapy. A case of basaloid squamous cell carcinoma with proliferation of bizarre mesenchymal component is being reported here with an updated literature review. Keywords Basaloid · Epithelial mesenchymal transition · Glottis · Spindle cell Introduction Here, we report a glottic basaloid squamous cell carci- noma showing a substantial spindle cell component extend- Basaloid squamous cell carcinoma (BSCC) of the head and ing to sub-glottis and right pyriform sinus (hypopharynx) neck is considered to be an uncommon malignancy with an with emphasis on histological differential diagnosis and unfavorable clinical outcome. In 1986, Wain et al. reported review of literature. the first head and neck case [1 ]. In rare instances, a bipha- sic histological presentation comprising of basaloid squa- mous cell carcinoma with spindle cell component has been Case Presentation reported in various sites such as

Journal

Head and Neck PathologySpringer Journals

Published: Jun 5, 2018

References

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