Lamotrigine in the Treatment of Unipolar Depression with and Without Comorbidities: A Literature Review

Lamotrigine in the Treatment of Unipolar Depression with and Without Comorbidities: A Literature... To review the available data behind the use of lamotrigine in unipolar depression and common comorbid conditions. A PubMed based literature review was conducted using keywords related to lamotrigine, depression, anxiety, post traumatic stress disorder (PTSD), obsessive–compulsive disorder (OCD), and personality disorders. A large number of trials using lamotrigine for unipolar depression and various comorbid conditions were reviewed. A major limitation behind the majority of studies was a limited course of the treatment phase. The most robust data was found among studies that followed patients for over 8 weeks, and used higher dosages. Patients with comorbid anxiety states appeared to benefit. Patients with borderline personality disorder also appeared to benefit. The benefits of lamotrigine in unipolar depression have been inconsistently noted in a number of studies. This is due in part to short treatment phases, atypical domains of benefit and different patient populations across studies. Patients with more treatment-resistance, comorbid anxiety and borderline personality disorder may be more able to benefit from lamotrigine. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychiatric Quarterly Springer Journals

Lamotrigine in the Treatment of Unipolar Depression with and Without Comorbidities: A Literature Review

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Publisher
Springer US
Copyright
Copyright © 2012 by Springer Science+Business Media, LLC
Subject
Medicine & Public Health; Psychiatry; Public Health; Sociology, general
ISSN
0033-2720
eISSN
1573-6709
D.O.I.
10.1007/s11126-012-9208-4
Publisher site
See Article on Publisher Site

Abstract

To review the available data behind the use of lamotrigine in unipolar depression and common comorbid conditions. A PubMed based literature review was conducted using keywords related to lamotrigine, depression, anxiety, post traumatic stress disorder (PTSD), obsessive–compulsive disorder (OCD), and personality disorders. A large number of trials using lamotrigine for unipolar depression and various comorbid conditions were reviewed. A major limitation behind the majority of studies was a limited course of the treatment phase. The most robust data was found among studies that followed patients for over 8 weeks, and used higher dosages. Patients with comorbid anxiety states appeared to benefit. Patients with borderline personality disorder also appeared to benefit. The benefits of lamotrigine in unipolar depression have been inconsistently noted in a number of studies. This is due in part to short treatment phases, atypical domains of benefit and different patient populations across studies. Patients with more treatment-resistance, comorbid anxiety and borderline personality disorder may be more able to benefit from lamotrigine.

Journal

Psychiatric QuarterlySpringer Journals

Published: Feb 10, 2012

References

  • Outcomes of add-on treatment with lamotrigine in partial epilepsy
    Smith, D; Baker, G; Davies, G; Dewey, M; Chadwick, DW
  • Lamotrigine adjunctive treatment in resistant unipolar depression: an open, descriptive study
    Gabriel, A
  • Placebo-controlled trial of lamotrigine added to conventional and atypical antipsychotics in schizophrenia
    Kremer, I; Vass, A; Gorelik, I; Bar, G; Blanaru, M; Javitt, DC; Heresco-Levy, U

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