L protein, the RNA-dependent RNA polymerase of hantaviruses

L protein, the RNA-dependent RNA polymerase of hantaviruses L protein of hantaviruses is the RNA transcriptase and replicase that transcribes mRNAs and replicates the genomic RNA using antigenomic RNA as an intermediate. It also appears to have endonuclease activity. In this review, the current knowledge on the hantavirus L protein is presented including sequence motifs conserved in RNA polymerases, mechanisms of RNA synthesis and also the most recent findings on homologous RNA recombination and membrane association. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

L protein, the RNA-dependent RNA polymerase of hantaviruses

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Publisher
Springer-Verlag
Copyright
Copyright © 2005 by Springer-Verlag/Wien
Subject
Biomedicine; Medical Microbiology; Virology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-004-0414-8
Publisher site
See Article on Publisher Site

Abstract

L protein of hantaviruses is the RNA transcriptase and replicase that transcribes mRNAs and replicates the genomic RNA using antigenomic RNA as an intermediate. It also appears to have endonuclease activity. In this review, the current knowledge on the hantavirus L protein is presented including sequence motifs conserved in RNA polymerases, mechanisms of RNA synthesis and also the most recent findings on homologous RNA recombination and membrane association.

Journal

Archives of VirologySpringer Journals

Published: Mar 1, 2005

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