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l-Proline catalyzed facile and efficient synthesis of functionalized indol-3-yl pyran derivatives by multi-component reactions

l-Proline catalyzed facile and efficient synthesis of functionalized indol-3-yl pyran derivatives... A simple and green synthetic method for preparation of functionalized indol-3-yl pyran derivatives was developed. The reactions were carried out by one-pot three-component synthesis of 3-cyanoacetyl indoles, malononitrile/cyanoacetate and various aldehydes/isatins/acenaphthenequinone in the presence of catalytic amount of l-proline. The advantages of this method included straightforward processing, excellent yields, broad substrate scope and environmental friendliness. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

l-Proline catalyzed facile and efficient synthesis of functionalized indol-3-yl pyran derivatives by multi-component reactions

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References (54)

Publisher
Springer Journals
Copyright
Copyright © 2017 by Springer Science+Business Media Dordrecht
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
DOI
10.1007/s11164-017-2897-4
Publisher site
See Article on Publisher Site

Abstract

A simple and green synthetic method for preparation of functionalized indol-3-yl pyran derivatives was developed. The reactions were carried out by one-pot three-component synthesis of 3-cyanoacetyl indoles, malononitrile/cyanoacetate and various aldehydes/isatins/acenaphthenequinone in the presence of catalytic amount of l-proline. The advantages of this method included straightforward processing, excellent yields, broad substrate scope and environmental friendliness.

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Feb 22, 2017

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