-Proline catalyzed facile and efﬁcient synthesis
of functionalized indol-3-yl pyran derivatives
by multi-component reactions
Received: 28 November 2016 / Accepted: 2 February 2017 / Published online: 22 February 2017
Ó Springer Science+Business Media Dordrecht 2017
Abstract A simple and green synthetic method for preparation of functionalized
indol-3-yl pyran derivatives was developed. The reactions were carried out by one-
pot three-component synthesis of 3-cyanoacetyl indoles, malononitrile/cyanoacetate
and various aldehydes/isatins/acenaphthenequinone in the presence of catalytic
-proline. The advantages of this method included straightforward pro-
cessing, excellent yields, broad substrate scope and environmental friendliness.
Keywords Indol-3-yl pyran Á
-Proline catalyst Á Multi-component reactions
Multi-component reactions (MCRs) has been developed as one of the most powerful
tools for the synthesis of structurally complex, biologically active and drug-like
compounds [1–3], for their convergence, productivity, easy execution, excellent
yields and atom economy characters [4–7].
Jing Wang, Hongzhi Liu and Ren Wen have contributed equally to this work.
Electronic supplementary material The online version of this article (doi:10.1007/s11164-017-2897-4)
contains supplementary material, which is available to authorized users.
& Songlei Zhu
Department of Chemistry, School of Pharmacy, Xuzhou Medical University, Xuzhou 221004,
Shenzhen College of International Education, Shenzhen 518048, China
Zhengda Tianqing Pharmaceutical Group Co. LTD, Lianyungang 222062, China
Res Chem Intermed (2017) 43:4575–4583