J. Membrane Biol. 181, 67–76 (2001) The Journal of DOI: 10.1007/s00232-001-0011-7 Membrane Biology © Springer-Verlag New York Inc. 2001 Topical Review S.W. Schneider Department of Physiology, University of Mu ¨ nster, Germany Received: 31 March 2000/Revised: 30 September 2000 Introduction Exocytosis and Vesicle Cycling Membrane fusion involves the merging of two phospho- Secretion of cellular content, stored in vesicles, is a fun- lipid bilayers and is a regular occurrence in eukaryotic damental process which requires assembly of distinct cells. Intracellular vesicle targeting and subsequent proteins as well as merging of two lipid bilayers. Exo- membrane fusion regulate protein processing and sort- cytosis can be induced by specific secretagogues (regu- ing, intracellular digestion, integrity and dynamics of lated exocytosis) or can occur constitutively. Our cellular compartments as well as cell growth and prolif- knowledge about proteins involved in vesicle fusion has eration. Fusion of vesicles with the plasma membrane expanded dramatically during the last 5 years. Nonethe- has three aims: the first is to incorporate integral mem- less, little is known about the morphological aspects of brane proteins, such as ion transporters or ion channels, vesicle fusion. The classical model of exocytosis, also etc., into the cell membrane. The second
The Journal of Membrane Biology – Springer Journals
Published: Feb 1, 2014
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