Kinetic scavenging effect of chinonin on no and oxygen free radicals generated from ischemia reperfusion myocardium and its protective effect on the myocardium

Kinetic scavenging effect of chinonin on no and oxygen free radicals generated from ischemia... The kinetic scavenging effect of chinonin on NO and oxygen free radicals generated from ischemia reperfusion myocardium and its protective effect on the myocardium were studied by electron spin resonance (ESR) spin trapping technique. It was found that after 20 minutes ischemia, the first peak of oxygen free radical appeared at about 0.5 minutes after the beginning of reperfusion, then the release of oxygen free radicals decreased with time. The second peak appeared at about 3 minutes. Similarly, there were two peaks of creatine kinase (CK) release, which indicated the myocardial damage, the first one appeared concomitantly with the first oxygen free radical peak but the second one appeared later about 1 minute after appearance of the second peak of oxygen free radicals. The release of NO free radicals was not significant in the absence of L-arginine. However, it increased significantly in the presence of L-arginine and it also possesses a biphase profile. It could protect the ischemia-reperfusion damage in the presence of low concentration of L-arginine (0.1 mM), but in high L-arginine concentration (10 mM) it generated higher concentrations of NO leading to a more serious ischemia-reperfusion damage. Addition of chinonin could scavenge the free radicals and protect the ischemia-reperfusion injury, especially in the second phase. The reduction stoichiometry of chinonin for Fe(III) was measured. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Kinetic scavenging effect of chinonin on no and oxygen free radicals generated from ischemia reperfusion myocardium and its protective effect on the myocardium

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Publisher
Springer Journals
Copyright
Copyright © 2000 by Springer
Subject
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1163/156856700X00660
Publisher site
See Article on Publisher Site

Abstract

The kinetic scavenging effect of chinonin on NO and oxygen free radicals generated from ischemia reperfusion myocardium and its protective effect on the myocardium were studied by electron spin resonance (ESR) spin trapping technique. It was found that after 20 minutes ischemia, the first peak of oxygen free radical appeared at about 0.5 minutes after the beginning of reperfusion, then the release of oxygen free radicals decreased with time. The second peak appeared at about 3 minutes. Similarly, there were two peaks of creatine kinase (CK) release, which indicated the myocardial damage, the first one appeared concomitantly with the first oxygen free radical peak but the second one appeared later about 1 minute after appearance of the second peak of oxygen free radicals. The release of NO free radicals was not significant in the absence of L-arginine. However, it increased significantly in the presence of L-arginine and it also possesses a biphase profile. It could protect the ischemia-reperfusion damage in the presence of low concentration of L-arginine (0.1 mM), but in high L-arginine concentration (10 mM) it generated higher concentrations of NO leading to a more serious ischemia-reperfusion damage. Addition of chinonin could scavenge the free radicals and protect the ischemia-reperfusion injury, especially in the second phase. The reduction stoichiometry of chinonin for Fe(III) was measured.

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Jul 7, 2009

References

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