Ketamine-induced behavioural and brain oxidative changes in mice: an assessment of possible beneficial effects of zinc as mono- or adjunct therapy

Ketamine-induced behavioural and brain oxidative changes in mice: an assessment of possible... Rationale We studied the influence of zinc, haloperidol or ide and MDA levels, while it decreased working memory, olanzapine on neurobehaviour (open-field, radial arm maze social interaction and glutathione. Administration of zinc and elevated plus maze) and brain antioxidant status in alone or in combination with haloperidol or olanzapine was vehicle- or ketamine-treated mice, with the aim of ascertaining associated with variable degrees of reversal of these effects. the potentials of zinc in counteracting ketamine’seffects. Conclusion Zinc may have the potential of a possible thera- Objectives Experiment 1 assessed the effects of zinc in peutic agent and/or adjunct in the reversal of schizophrenia- healthy animals and the relative degrees of modulation of like changes in behaviour and brain oxidative status. ketamine’s effects by zinc, haloperidol or olanzapine, respec- . . . tively. Experiment 2 assessed the modulation of ketamine’s Keywords Antipsychotic Ketamine Trace element . . . effects following co-administration of zinc with haloperidol Memory Schizophrenia Social interaction Oxidative stress or olanzapine. Methods Male mice weighing 18–20geachwere used. Animals were pretreated with ketamine (except vehicle, zinc, Introduction haloperidol and olanzapine controls) for 10 days before com- mencement of 14-day treatment (day 11–24) with vehicle, Mental health disorders (like schizophrenia) http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Ketamine-induced behavioural and brain oxidative changes in mice: an assessment of possible beneficial effects of zinc as mono- or adjunct therapy

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Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by Springer-Verlag GmbH Germany
Subject
Biomedicine; Neurosciences; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
D.O.I.
10.1007/s00213-017-4666-x
Publisher site
See Article on Publisher Site

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