OH CN OH HO O NH OH CHO K CO / Cyanuric acid 2 3 CN NC CN H O, r.t O NH CN O NH & Reza Heydari email@example.com Department of Chemistry, The University of Sistan and Baluchestan, P.O. Box 98135-674, Zahedan, Iran 123 4612 R. Heydari et al. Keywords 2-Amino-4H-chromene Aldehyde Cyanuric acid Potassium carbonate Green chemistry Water Introduction The main challenges in recent decades in organic chemistry are the synthesis of new compounds with economical, high-efﬁciency and eco-friendly processes. According to the principles of ‘‘Green Chemistry’’, energy requirements should be recognized for their environmental impacts and should be minimized. Synthetic methods should be conducted at ambient pressure and temperature, also using solvent-free or recyclable environmentally benign solvent systems. In this regard, water can be the best replacement for an rganic solvent, as it is nonvolatile, nonﬂammable, nontoxic, and inexpensive [1, 2]. Chromenes consist of bicyclic oxygen heterocycles resulting from the fusion of the benzene ring with 5, 6-positions of either a 2H- or a 4H-pyran ring system are designated as 2H-chromene and 4H-chromene (Fig. 1). The diverse pharmaco- logical activities of this class of molecules, with antimicrobial  anti-antiviral , anti-inﬂammatory
Research on Chemical Intermediates – Springer Journals
Published: Feb 17, 2017
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