K2CO3/cyanuric acid catalyzed synthesis of 2-amino-4H-chromene derivatives in water

K2CO3/cyanuric acid catalyzed synthesis of 2-amino-4H-chromene derivatives in water OH CN OH HO O NH OH CHO K CO / Cyanuric acid 2 3 CN NC CN H O, r.t O NH CN O NH & Reza Heydari heydari@chem.usb.ac.ir Department of Chemistry, The University of Sistan and Baluchestan, P.O. Box 98135-674, Zahedan, Iran 123 4612 R. Heydari et al. Keywords 2-Amino-4H-chromene  Aldehyde  Cyanuric acid  Potassium carbonate  Green chemistry  Water Introduction The main challenges in recent decades in organic chemistry are the synthesis of new compounds with economical, high-efficiency and eco-friendly processes. According to the principles of ‘‘Green Chemistry’’, energy requirements should be recognized for their environmental impacts and should be minimized. Synthetic methods should be conducted at ambient pressure and temperature, also using solvent-free or recyclable environmentally benign solvent systems. In this regard, water can be the best replacement for an rganic solvent, as it is nonvolatile, nonflammable, nontoxic, and inexpensive [1, 2]. Chromenes consist of bicyclic oxygen heterocycles resulting from the fusion of the benzene ring with 5, 6-positions of either a 2H- or a 4H-pyran ring system are designated as 2H-chromene and 4H-chromene (Fig. 1)[3]. The diverse pharmaco- logical activities of this class of molecules, with antimicrobial [4] anti-antiviral [5], anti-inflammatory http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

K2CO3/cyanuric acid catalyzed synthesis of 2-amino-4H-chromene derivatives in water

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Springer Netherlands
Copyright © 2017 by Springer Science+Business Media Dordrecht
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
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