Rationale Social isolation of rats immediately after weaning female rats decreases maternal behavior; this effect is associ- is thought to represent an animal model of anxiety-like disor- ated with lower allopregnanolone concentrations at postpar- ders. Socially isolated virgin females showed a significant tum, which may account, at least in part, for the poor maternal decrease in allopregnanolone levels, associated with increased care observed in socially isolated dams. In support of this anxiety-related behavior compared with group-housed rats. conclusion is the finding that finasteride-treated dams, which Objectives The present study investigates whether post- display a decrease in plasma allopregnanolone levels, also weaning social isolation affects maternal behavior and as- showed a marked reduction in maternal care, suggesting that sesses neuroactive steroid levels in adult female rats during allopregnanolone may contribute to the quality of maternal pregnancy and postpartum. care. Results Socially isolated dams displayed a reduction in the frequency of arched back nursing (ABN) behavior compared . . Keywords Social isolation Allopregnanolone Maternal . . to group-housed dams. In addition, both total and active nurs- care Female rat Finasteride ing were lower in socially isolated dams compared to group- housed dams. Compared to virgin females, pregnancy in- creases allopregnanolone levels
Psychopharmacology – Springer Journals
Published: Jun 16, 2017
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