J Membrane Biol (2016) 249:3 DOI 10.1007/s00232-016-9900-7 Diane Lidke Published online: 18 April 2016 Springer Science+Business Media New York 2016 The Journal of Membrane Biology has historically pub- transduction stations. Recent studies have demonstrated the lished studies on the role of membranes in regulating cell existence of lipid domains in the nuclear membrane. In biology processes. This has included topics such as mem- addition, specialized intracellular membrane organelle brane protein structure–function, membrane-mediated sig- contact sites are an area of intense investigation, which we naling mechanisms, and cell–cell communication. The new believe can ﬁnd in our journal a new forum. section ‘‘Cell Biology’’ will continue these themes, while at Common to all biomembranes are the still poorly under- the same time opening up to a broader range of topics. In stood topics of transbilayer coupling, leaﬂet asymmetry, and this context, we are interested in manuscripts that focus on membrane curvature. While long-chain lipids have been the crucial role for lipid membranes in all types of cellular implicated in the transbilayer coupling of the plasma mem- processes, ranging from plasma membrane organization to brane, the details of this process still remain to be elucidated. vesicle trafﬁcking to mechanical sensing. Moreover, it is unknown if similar coupling mechanisms It is now well recognized that the plasma membrane has exist in organelles. Membrane geometry is known to play an a nanoscale organization. In the more than 40 years since important role in membrane protein distribution, and spe- Singer & Nicholson put forth the Fluid Mosaic Model, a cialized membrane invaginations such as caveolae have been number of mechanisms through which the membrane is implicated in sensing of mechanical cues. A current chal- organized have been reported. This journal still aims at lenge is to increase our understanding of these physical– providing a platform for studies about lipid rafts, actin chemical principles and how they affect cellular outcomes. corrals, tetraspanins, and other nanoclustering mechanisms. Finally, we believe that quantitative studies integrating Particularly, exciting is the potential role of the glycan information from multiple disciplines are fundamental to moieties conjugated to proteins and lipids in regulating advancing the ﬁeld of membrane biology. Techniques such membrane organization and dynamics. An ultimate goal of as lipidomics, organelle isolation, and high-resolution this section is to increase our understanding of how imaging have provided insights into the composition and membrane compartments regulate signal transduction in organization of biomembranes with unprecedented detail. time and space. Therefore, the application of cutting-edge, quantitative Membrane organization within internal cellular com- techniques will have a prominent place in the pages of partments is also gaining importance. For example, nan- JMBi. We hope that our readership will identify with this odomains have been found in endosomes, putting forward newly deﬁned journal section and help us to establish a the concept that endosomes are in fact intracellular signal vibrant new community in this ﬁeld. & Diane Lidke firstname.lastname@example.org Department of Pathology, Cancer Research Facility, School of Medicine, University of New Mexico, Room 203, Albuquerque, NM 87131, USA
The Journal of Membrane Biology – Springer Journals
Published: Apr 18, 2016
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