Pathology & Oncology Research https://doi.org/10.1007/s12253-018-0443-3 LETTER TO THE EDITOR JAK Pseudokinase Domain Variants Highlight nRTK VUSs Identified with Next-Generation Sequencing in Solid Tumor Patients 1,2 3 1 Matthew K. Stein & Lindsay K. Morris & Mike G. Martin Received: 21 November 2017 /Accepted: 30 May 2018 Arányi Lajos Foundation 2018 Main Text undetermined significance (VUS) were included. All variants had >99% detection confidence based upon allele frequency Non-receptor tyrosine kinase (nRTK) pathways are aberrantly and amplicon coverage. In order to classify VUS, in silico activated in cancer, and mutations in nRTKs have potential analysis with PolyPhen-2 was utilized to predict pathogenicity therapeutic and prognostic importance. Consisting of 10 fam- . Any VUS predicted-damaging with in silico analysis we ilies, the 32 known human nRTKs each include a TKD made denote VUSp. VUSs were then classified as occurring within of N and C-terminal lobes necessary for catalytic activity, as or outside of the TKD; PSKD lesions were also detailed for well as varying regulatory regions including Src homology 2 JAK1–3. (SH2) and 3 (SH3), and in the case of the Janus kinases a 346 patients (79 breast, 110 colon and 157 non-small cell PSKD which is also bi-lobed . Tumor
Pathology & Oncology Research – Springer Journals
Published: Jun 3, 2018
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