Reactions 1704, p211 - 2 Jun 2018 Liver damage: case report A 61-year-old-woman developed liver damage during treatment with isoniazid for latent tuberculosis infection (LTBI) [dosage and route not stated]. She had been receiving anti- tubercular therapy with isoniazid for 5 months. She experienced poor appetite and abdominal distension of a week duration. She was found to have elevated levels of liver enzymes and serum bilirubin. Her liver damage was attributed to the administration of isoniazid. She received an unspecified treatment for three weeks, and a gradual improvement in her condition was observed. Author comment: "Generally, acute hepatitis caused by LTBI treatment with isoniazid is quite rare. At present, the exact mechanism of Isoniazid related hepatotoxicity is still unclear." Hsieh P-F, et al. Treatment of latent tuberculosis infection (LTBI) with isoniazid induce severe liver damage. International Journal of Antimicrobial Agents 50 (Suppl. 2): S260-S261 abstr. PS 517, Nov 2017 [abstract] - Taiwan 803323300 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704
Reactions Weekly – Springer Journals
Published: Jun 2, 2018
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